P66shc modulation for humans??

Thomas Carter tcarter2 at elp.rr.com
Sat May 18 11:05:43 EST 2002


Hi,
     P66shc is the gene that has been shown to shorten rodent's life
spans. (Lack of it lengthens their life by 30%.) Its purpose is to
cause apoptosis in cells subjected to oxidative stress.( PMID:
10580504 ) It is activated by a JNK kinase.  ( PMID: 11602589 ) 
Hsp72, the main heat shock protein inhibits JNK.   Its activity is
greatly reduced with age. ( PMID: 11602589 )   Hsp72 can be induced ,
even in aged cells, by AHIF, an enzyme found the the serous fluid of
the abdominal cavity of humans. ( PMID: 10585271)
    Thus a natural product produced by humans may be able to provide
us the benefits seen by P66shc -/- rats.   Of course there are several
long stretches in the potential causal chain, one of which will be the
cancer effect of the reduction in the apoptotic capacity. P53,  P21,
and RAS  are all in the downstream pathway of p66shc.  Hsp also has
repair functions as well as the function of prevention of apoptosis.
Prevention of apoptosis may not be as beneficial for humans as rats.
Thomas

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