High Cell Losses In Early Development?

michaelprice michaelprice at ntlworld.com
Tue Jan 21 17:18:45 EST 2003

Leonid Gavrilov <lagavril at midway.uchicago.edu> wrote in message
news:9259eb2.0301151708.1376436e at posting.google.com...
> Greetings,
> I would appreciate your feedback on the issue of high cell losses in
> early development (this may be important for understanding aging).
> Specifically, I wonder whether the following statement is correct:
>  "The female human fetus at age 4-5 months possesses 6-7 million eggs
> (oocytes). By birth, this number drops to 1-2 million and declines
> even further.  At the start of puberty in normal girls, there are only
> 0.3-0.5 million eggs -- just only 4-8% of initial numbers."

I have heard this before in several places so I would guess it's true.

> Are there any other similar examples of early massive cell loss?

> Or is this story specific to oocytes only?

Early CNS neuronal losses are massive also, although it is believed to be
part of the early learning process rather than anything to do with aging.

Michael C Price

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