[Annelida] The bits you share with the Platynereis genome

Geoff Read g.read at niwa.co.nz
Thu Feb 9 19:55:31 EST 2006

An article in Science last November seems to be having spin off.


Where is the difference between the genomes of humans and annelids?
Alexei Fedorov, Larisa Fedorova
Genome Biology 2006 7:203 
Abstract  = http://genomebiology.com/2006/7/1/203/abstract
Full Text = http://genomebiology.com/2006/7/1/203
PDF       = http://genomebiology.com/2006/7/1/203/pdf

The first systematic investigation of an annelid genome has revealed that the
genes of the marine worm Platynereis dumerilii are more closely related to
those of vertebrates than to those of insects or nematodes. For hundreds of
millions of years vertebrates have preserved exon-intron structures descended
from their last common ancestor with the annelids


Raible, F.et al.* 2005: Vertebrate-Type Intron-Rich Genes in the Marine 
Annelid Platynereis dumerilii. Science 310: 1325-1326. (25 November, 2005)

*Raible, Florian; Tessmar-Raible, Kristin; Osoegawa, Kazutoyo; Wincker, 
Patrick; Jubin, Claire; Balavoine, Guillaume; Ferrier, David; Benes, Vladimir; 
de Jong, Pieter; Weissenbach, Jean; Bork, Peer; Arendt, Detlev


Previous genome comparisons have suggested that one important trend in 
vertebrate evolution has been a sharp rise in intron abundance. By using 
genomic data and expressed sequence tags from the marine annelid Platynereis 
dumerilii, we provide direct evidence that about two-thirds of human introns 
predate the bilaterian radiation but were lost from insect and nematode 
genomes to a large extent. A comparison of coding exon sequences confirms the 
ancestral nature of Platynereis and human genes. Thus, the urbilaterian 
ancestor had complex, intron-rich genes that have been retained in Platynereis 
and human.

  Geoff Read <g.read at niwa.co.nz>

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