Postdoctoral positions available

Thu Feb 27 16:16:00 EST 1992


Postdoctoral Positions
University of Wisconsin-Madison 

     Two postdoctoral positions are available starting in the
summer of 1992 to study the biochemistry, molecular biology, and
genetics of the ubiquitin-dependent proteolytic pathway in plants
with a focus on Arabidopsis thaliana.  Successful applicants will
join a larger research group currently using a variety of techniques
to define the pathway's role in plant metabolism, development,
growth, and response to stress.  Projects are flexible depending on
the nature and interests of the candidates. Possibilities include:
(i) development of ubiquitin fusion vectors to enhance protein
accumulation in transgenic plants (see Science January 3, 1992, pg
25), (ii) cloning and analysis of enzymes involved in ubiquitin
conjugation [see Sullivan and Vierstra (1991) J. Biol. Chem. 266:
23878-23885; van Nocker and Vierstra (1991) Proc. Natl. Acad
Sci USA 88: 10297-10301], (iii) expression of such genes in
transgenic plants [see Callis et al. (1990) J. Biol. Chem.
265:12486-12493], (iv) and understanding how the ubiquitin
system decides which proteins are appropriate substrates for
degradation with special emphasis on the selective degradation of
the photomorphogenic receptor, phytochrome [see Cherry et al.
(1991) Plant Physiol. 96: 775-785].  Experience in molecular and
biochemical techniques is necessary, but prior work with plants is
not required.  Position has a starting salary of ~$22,000/yr plus
benefits, which may be renewed for at least 3 years.  Interested
candidates should send a resume and the names of three references
to Dr. Richard D. Vierstra, Department of Horticulture and the
Cellular and Molecular Biology Program, University of Wisconsin-
Madison, Madison, WI  53706 or contact him by phone [(608)
262-8215, office; (608) 262-4743, FAX]. 

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