postdoctoral positions

Patrick S Schnable schnable at iastate.edu
Tue Apr 19 17:48:39 EST 1994


Two Postdoctoral Positions 

Two postdoctoral positions are available to conduct
research on an on-going collaborative project on the
relationship between chromosomal structure and function. 

One postdoctoral associate will conduct research on the
fine-structure physical analysis of the cloned a1-sh2
interval from the long arm of the maize chromosome 3. 
The a1 and sh2 genes are separated by 0.09 cM.  This
genetic interval has been cloned as a single 470-kb YAC. 
The physical distance between these genes has been
established to be 140 kb.  This achievement has enabled us
to determine, for the first time in a complex plant genome,
the relationship between the genetic and physical distances
over a molecularly cloned interval larger than a single gene
(Civardi et al., PNAS, in press).  Current research efforts
are directed towards understanding the relationship
between meiotic recombination and physical landmarks in
the genome.  The availability of an extensive collection of
meiotic recombinants between the a1 and sh2 loci (>1/kb)
will facilitate these analyses.  Experience with molecular
biological techniques is essential; familiarity with YACs
and/or yeast genetics is desired.  Available immediately.

For more information, contact:

Dr. Basil J Nikolau
Dept of Biochemistry & Biophysics
Iowa State University
Ames, IA  50011
voice:  515-294-9423
fax:    515-294-0453
e-mail: dimmas at iastate.edu

The other postdoctoral associate will conduct research on
the genetic and molecular characterization of a mini-
chromosome in maize with an ultimate goal of isolating a
plant centromere.  The mini-chromosome contains several
selectable and/or screenable genetic markers derived from
the cloned a1-sh2 interval of chromosome 3.  Therefore
this mini-chromosome is an ideal model for studying those
structural elements that are essential for chromosome
function (viz. the centromere).  Our cytological analyses
have established that the mini-chromosome is a ring of less
than 26 Mb in size.  An overlapping set of genetically
derived deletions of the mini-chromosome are being used in
conjunction with RFLP markers from the mini-chromosome
to define and ultimately clone the centromere.  Experience
with molecular biological techniques is essential; familiarity
with YACs and/or plant genetics is desired.  Available 1
January 1995.  


For more information on this position, contact:

Dr. Patrick S Schnable
Dept of Agronomy
Iowa State University
Ames, IA  50011
voice:  515-294-0975
fax:    515-294-2299
-- 
Patrick S Schnable
schnable at iastate.edu
G405 Agronomy, ISU
Ames IA  50011
515-294-0975 (voice)



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