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one gene (was: (none)).

Chuck Gasser csgasser at ucdavis.edu
Fri Aug 19 17:51:22 EST 1994

In article <199408182120.RAA25471 at acpub.duke.edu>
kohorn at ACPUB.DUKE.EDU writes:

> Does anyone know of a documented instance where there is one gene that
> encodes both an organelle and a cytoplasmic protein? This might arise via
> something like alternate transcription or splicing.

Neurospora crassa has a cyclophilin gene in which two different
transcription starts are utilized.  The longer transcript encodes a
preprotein which is targeted to the mitochondrial matrix.  In the
shorter transcript translation starts from an ATG right at the
beginning of the "mature" protein and the product remains in the
cytosol.  The reference for this is Tropschug et al. (1988) J. Biol.
Chem. 263:14433-14440.

Chuck Gasser
csgasser at ucdavis.edu

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