Postdoctoral Positions

Barbara Baker bbaker at GARNET.BERKELEY.EDU
Mon Aug 7 15:12:05 EST 1995


POSTDOCTORAL POSITIONS are currently available for isolation of disease
resistance genes (R genes) and molecular-genetic studies on receptor
mediated pathogen recognition and signal transduction leading to plant
disease resistance. Projects include: (1) identification of the TMV
elicitor of the receptor-like N protein, (2) isolation of the TMV
resistance gene, N', and (3) isolation of disease resistance genes related
to the NBS/LRR family of receptor-like R genes from barley.  The sequence
of several recently isolated R genes shows that they encode deduced
products with strikingly similar structural features.  It is postulated
that R genes encode receptors that perceive the pathogen signal and
initiate signal transduction pathways leading to expression of resistance
responses.  We have isolated the first virus resistance gene, N, of tobacco
(Whitham et al. 1994, Cell).  The amino-terminal domain of N shares
homology with the cytoplasmic domains of the interleukin-1 receptor (Il-1R)
the Drosophila Toll receptor protein.  The sequence similarity of N, Il-1R
and Toll suggests that N mediates rapid gene induction and TMV resistance
through an Il-1R/Toll-like signal transduction pathway.  Applicants should
have experience in biochemistry, molecular biology and/or cell biology,
however, prior work with plants is not required.  A cover letter describing
research experience and interests, a curriculum vitae and names of three
references should be sent to: Dr. Barbara Baker, University of California,
Berkeley and USDA, Plant Gene Expression Center, 800 Buchanan St., Albany,
CA 94710. FAX: 510-559-5678; Email: bbaker at garnet.berkeley.edu





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