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mendel's peas

Andy Phillips andy.phillips at bbsrc.ac.uk
Thu Feb 15 12:44:20 EST 1996

Greenberg Jean wrote:
> A colleague of mine has asked me what is known about the molecular basis
> of the various mutants that Mendel worked with.
> Thanks in advance,
> Jean Greenberg
> Assistant Professor
> U. Colorado, Boulder
> greenbej at beagle.colorado.edu

Mendel's dwarf mutant of pea, now designated 'le', is deficient in one the later 
enzymes in the gibberellin (GA) biosynthesis pathway. Le is believed to encode 
3-beta-hydroxylase (Ingram et al. 1984, Plants 160: 455-463), which catalyses the 
conversion of GA20 to GA1, the 'active' GA in many plants (to see the structure of 
GA1, see our Web page at http://www.lars.bbsrc.ac.uk/plantsci/hbg2.html). GAs act as 
plant growth regulators and are involved throughout the life cycle of the plant, from 
germination through flower induction and bolting (stem elongation) to fruit 

As far as I know, the Le gene has not yet been cloned, although the equivalent gene 
from Arabidopsis, GA4, was recently isolated by T-DNA tagging (Chiang et al. (1995) 
Plant Cell, 7: 195-201).


 Email  : andy.phillips at bbsrc.ac.uk  : University of Bristol
 Home   : andy at cycad.demon.co.uk     : IACR Long Ashton Research Station 
 Phone  : +44-1275-549257            : Long Ashton
 Fax    : +44-1275-394281            : Bristol, BS18 9AF, UK
 WWW    : http://www.lars.bbsrc.ac.uk/plantsci/molbiol/andy.html

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