braam at bioc.rice.edu
Mon Jul 6 14:02:14 EST 1998
Postdoctoral positions are available for investigation
of the TCH2 and TCH3 proteins of Arabidopsis. Biochemical,
genetic and cell biological approaches will be used. TCH2 and
TCH3 are unique calmodulin-related proteins; sequence divergence of
TCH2 and TCH3 from calmodulin strongly suggests that the functions
of these proteins are distinct from those of calmodulin.
Developmental expression of these TCH genes is found at sites
of mechanical strain, in expanding cells and/or in cells
undergoing turgor changes. Current hypotheses are that TCH2
may mediate calcium-regulation of ion channels and that TCH3
may function in vesicular transport. The TCH proteins are
being produced in heterologous cells and will be tested for
the ability to act as calmodulin in in vitro assays. Labeled
TCH proteins are being used to probe cDNA expression libraries
to identify potential target proteins. Transgenic and mutant
plants are being isolated and examined to determine the effects
of altered production of the TCH proteins in vivo.
(For background see: Cell 60, 357-364; PNAS 89,
3213-3216; Plant Cell 6, 1553-1565; Plant J. 8, 623-636;
Plant Cell 7, 1555-1567; Plant J. 9, 879-889; Proteins 27,
144-153; Planta 203, 535-541.)
A strong background in molecular biology, biochemistry
and Arabidopsis genetics is preferred. Only highly motivated
individuals with proven track records should apply. Applicants
should send a CV and a cover letter describing research experience
and interests, and the names, addresses and phone numbers of three
or four references to:
Dr. Janet Braam
Biochemistry and Cell Biology
6100 Main St.
Houston, TX 77005-1892
Applications will be reviewed until the position is filled.
Rice University is an affirmative action/equal opportunity employer.
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