Postdoc. Positions at The Sainbury Laboratory

jane.parker jane.parker at bbsrc.ac.uk
Thu Sep 2 21:03:43 EST 1999


SAINSBURY LABORATORY
John Innes Centre, Norwich, UK

Postdoctoral Scientists in Molecular Plant Pathology

Applications are invited for vacancies within the following research groups
at the Sainsbury Laboratory.

Plant Disease Resistance Signalling - Reference No. SL/665.
A three year BBSRC-funded postdoctoral scientist position in Dr Jane
Parker's group. Mutational analyses have identified several genes that are
essential components of an R gene-mediated disease resistance pathway in
Arabidopsis. The project aims to clone and functionally characterise two of
these genes and integrate them with previously cloned signalling genes of
this pathway. The project will have some technical support. Experience in
molecular biology and genetics and/or protein biochemistry is desirable.
Informal enquiries can be made (jane.parker at bbsrc.ac.uk).

Bacterial Molecular Genetics - Reference No. SL/673.
A BBSRC-funded postdoctoral scientist position to work with Dr Max Dow on
the activation of synthesis of pathogenicity factors in Xanthomonas
campestris by a diffusible signal molecule (Mol. Microbiol. 24:555-566,
1997). The project aims to investigate the role of a two component system
in sensing this factor and in signal transduction. A background in
bacterial molecular genetics is desirable.

The Molecular Biology of Virus Resistance in Plants - Reference No. SL/666.
A vacancy to work at postdoctoral level in Prof. David Baulcombe's group
funded for two years in the first instance. The project will focus on the
Rx gene in potato conferring resistance against potato virus X aiming to
generate a biochemical description of the interactions between the Rx
protein and other proteins in the infected cell. One of these interactions
is between Rx and the viral coat protein and has been characterised
genetically. Other interactions involve signalling components and are
uncharacterised. Experience in analysis of protein-protein and protein-RNA
interactions is required.

Viral Suppressors of Gene Silencing - Reference No. SL/667.
A further vacancy in Prof. David Baulcombe's group funded for two years in
the first instance to work on viral suppressors of gene silencing. Gene
silencing in transgenic plants is a manifestation of a natural antiviral
defence mechanism. Many viruses overcome this defence because they encode
suppressors of gene silencing. The project aims use these suppressors as
probes of the gene silencing mechanism using genetical and biochemical
approaches. Mutant screens will be developed to detect host and viral
functions required for the activity of the suppressors. There will also be
direct biochemical analysis of protein-RNA and protein-protein interactions
involved in suppression of silencing.

All vacancies are funded to the R&A1A scale and the salary on appointment
will be within the range £16,286 - £24,479 per annum. Applications with
full CV together with the name of two referees should be sent to the
Personnel Officer, John Innes Centre, Colney, Norwich, NR4 7UH quoting the
appropriate Reference No. The closing date for applications is Friday 1st
October 1999. Further information is available on the Sainsbury Laboratory
web site: www.jic.bbsrc.ac.uk/Sainsbury-Lab.

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