Postdoctoral postions in cell signaling and transport

Nobody nobody at hgmp.mrc.ac.uk
Fri Feb 9 08:23:20 EST 2001


Dear Netters!
=20  Please find below details of three postdoctoral positions opening
with me as I move to Glasgow University.  The positions will be
advertised in Nature shortly.

University of Glasgow
Institute of Biomedical & Life Sciences

Postdoctoral Research Associates in
PLANT CELL SIGNALLING, ION CHANNELS
AND MEMBRANE FUNCTIONAL GENOMICS

Three posts funded by the BBSRC (RA1A, =A316,775 - =A325,213 per annum)
are available within the Laboratory of Plant Physiology and Biophysics
under Prof. Mike Blatt, recently appointed Regius Professor of Botany.
The successful candidates will join a dynamic, international research
group with ongoing programmes to characterise the mechanisms and
control of membrane traffic and ion channels in plant and fungal cell
models.  Work in each case will make use of molecular genetic,
biochemical, and/or electrophysiological/imaging techniques.  Prior
experience in one or more of these areas will be an advantage, but is not
a prerequisite as training will be available.

Post PCS1:   Syntaxin-protein interactions in ABA-coupled membrane
trafficking
The project is to identify and characterise proteins interacting with the
plasma membrane syntaxin NtSyr1, and builds on evidence for its role in
ABA signal transduction and related stress responses [Leyman, et al.
(1999) Science 283,537; ibid. (2000) Plant J. 24,369].  The work will make
use of molecular genetic, protein affinity and immunochemical tools
developed in the laboratory and is likely to take advantage of in vivo
analyses using confocal fluorescence imaging and related techniques.

Post PCS2:  ABA- and elicitor-mediated control of Ca2+ channels
Work on this project is directed to exploring the role of a novel class of
voltage-activated plasma membrane Ca2+ channels in evoked Ca2+ signal
processing in using stomatal guard cells as a cell model [Grabov and
Blatt (1998) PNAS 95,4778; Hamilton, et al. (2000) PNAS 97,4967].
Opportunities will include exploring Ca2+ signal interaction with secretory
events mediated by NtSyr1 and associated protein partners (above).  A
combination of electrophysiological and Ca2+ fluorescence imaging
techniques will be employed.

Post PCS3:  Structure/function analysis of K+ channel gating
Work on this project will fully map the structural features of the YKC1 K+
channel protein that determine the K+-binding sites associated with
voltage-sensitive gating of this channel [Vergani, et al. (1998) EMBO J.
17,7190; Vergani and Blatt (1999) FEBS Lett. 458,285].  Additional work
may involve collaborations in ongoing studies to determine the role(s) of
vesicle trafficking in control of the KAT1 K+ channel.  Site-directed
mutagenesis, heterologous expression and electrophysiological (whole-
cell and single-channel) analyses will form the core techniques of this
project.


The Laboratory of Plant Physiology and Biophysics

The Laboratory recently relocated from Imperial College at Wye
following the appointment of Prof. Blatt to the Regius Chair of Botany
within the Plant Molecular Science Group of the IBLS Division of
Biochemistry and Molecular Biology.  It is housed in the newly-
refurbished Stevenson Wing of the Bower Building.  Research within the
Laboratory focuses on fundamental problems of plant growth, cellular
signalling and homeostasis.  Three main themes currently under
investigation are (1) the physiology and molecular genetics of ion
channels and the mechanism(s) of their control, (2) the role of Ca2+ and
pH hormonal and abiotic stress signalling, and (3) the molecular
mechanisms of membrane trafficking in these processes. A component of
this work draws on electrophysiological and related studies, notably
using stomatal guard cells as a higher-plant cell model as well as other
single-cell systems.  The Laboratory currently holds over =A31M in external
research grants and contracts.  It enjoys ongoing collaborative links with
the University of Oxford, the CNRS (Paris), the John Innes Centre
(Norwich) and with research groups at Leuven, Darmstadt, Freiburg,
Pullman (USA) and Tokyo, among others.


Plant Sciences in Glasgow

Glasgow University has a strong tradition in the plant sciences, which is
embedded within several different research groups in the University. In
particular, there are flourishing groups within two of the Divisions of the
Institute of Biomedical and Life Sciences (IBLS), namely the Division of
Biochemistry and Molecular Biology (rated 5 in the last research
assessment exercise) and the Division of Environmental and
Evolutionary Biology (rated 4 in the last research assessment exercise).
There is also top-class plant research in the Agricultural, Food and
Environmental Chemistry section of the Department of Chemistry.

One of four research groups in the Division of Biochemistry and
Molecular Biology, the Plant Molecular Sciences Group comprises eight
members and is presently filling two new Lectureship appointments.  The
Group has excellent lab accommodation and equipment, and this past
year was awarded a =A33.9M grant for major refurbishment to the Bower
Building in which it is housed.  Facilities available include analytical and
proteomics suites, DNA sequencing and  new MALDI-TOF units,
electron, confocal and fast CCD imaging microscopes. There are
extensive plant growth facilities, including suites for tissue culture and
transgenic plants.  Research within the Plant Molecular Science Group
involves over fifty research staff and students, and divides between
several important areas: cellular signalling; the environmental and
metabolic regulation of gene expression; protein phosphorylation in the
control of metabolic activity and circadian rhythms; the structure,
function and regulation of membrane proteins including ion channels;
responses to biotic and abiotic stress; the dietary and nutritional
qualities of plant products; cell wall biochemistry and viral disease
resistance. The Group is well supported by the research councils,
charitable bodies and industry. There are strong contacts with
collaborating researchers both within the University (in IBLS, in the
Department of Human Nutrition and in the Department of Chemistry) and
in other institutions in the UK and overseas.


Staff in the Plant Sciences

Plant Molecular Science Group (Division of Biochemistry and
Molecular Biology)
Prof. MICHAEL R. BLATT (Regius Professor of Botany): Structure,
function and regulation of ion channels and secretory proteins
Dr. CHRISTOPHER T. BRETT: Biochemistry of plant cell walls
Prof. ALAN CROZIER: Biochemistry of secondary metabolites,
particularly flavonoids
Dr. PETER DOMINY: Adaptation and salinity tolerance to higher plants
Prof.. GARETH I. JENKINS: Photocontrol of gene expression, UV and
blue light signal transduction
Dr JOEL J. MILNER: Plant rhabdoviruses, viral infection and plant gene
expression
Prof. HUGH G. NIMMO: Metabolic regulation, control of
phosphoenolpyruvate carboxylase
Dr. CHRISTOPHER T. WHEELER: Symbiotic nitrogen fixation
Prof. ROGER L.P. ADAMS: DNA methylation
Prof. RICHARD J. COGDELL (Hooker Professor of Botany): Light
reactions of photosynthesis
Prof. JOHN R. COGGINS: Substrate recognition and design of enzyme
inhibitors
Prof. J. GORDON LINDSAY: Targeting, assembly and regulation of plant
2-oxoacid dehydrogenase complexes

Division of Environmental and Evolutionary Biology
Dr. DON CLARKE: Plant/fungus relations
Prof. JIM DICKSON: Plant taxonomy; palaeoecology; archaeobotany
Dr. KEVIN MURPHY: Functional analysis of plant communities

Department of Chemistry
Prof. NEIL W. ISAACS: Protein crystallography
Dr. MICHAEL C. JARVIS: The chemistry of plant cell walls
Prof. DAVID J. ROBINS: Synthesis and biological evaluation of novel
compounds

Terms and Conditions of Appointment
Appointments will be made on the RA1A scale (=A316,775 - =A325,213 per
annum) depending on experience and will be subject to the normal
Glasgow University probationary arrangements.  There will be
opportunity to join the Universities=92 Superannuation Scheme. Further
information regarding this scheme is available from the Superannuation
Officer, who is also prepared to advise on questions relating to the
transfer of benefits.


Informal Enquiries

Please contact Prof. Mike Blatt [phone (+44 (0)141) 330-4771 or (+44
(0)207) 594-2771; email m.blatt at bio.gla.ac.uk].

Applications

Applications should include a covering letter indicating for which
post(s) the application is made.  All applications should comprise two
copies of the following: a Curriculum Vitae and publications list, a
summary of research experience, the names, postal and e-mail addresses,
and phone numbers of three academic referees.  Address applications to
Ms. Allison Bertram, IBLS, West Medical Building, University of
Glasgow, G12 8QQ. Please enclose an Equal Opportunities monitoring
form with your application
(http://www.gla.ac.uk/services/personnel/recruit/equalop.htm).  Closing
date, 15. March 2001.  Screening of applicants will begin immediately.

=46urther details are available at these sites:
http://www.gla.ac.uk/ibls/BMB/mrb/
http://www.gla.ac.uk/ibls/BMB/index.htmlhttp://www.gla.ac.uk/services/h
umanresources/recruit/index.html
!!! NOTE NEW ADDRESSES AND PHONE NUMBER!!!
*********
Prof. M.R. Blatt
Laboratory of Plant Physiology and Biophysics
Imperial College at Wye
Wye, Kent TN25 5AH

email: m.blatt at ic.ac.uk
=20       m.blatt at bio.gla.ac.uk
phone: (+44 (0)20)7594 2771
fax: (+44 (0)20) 7594 2640
mobile: 0789 907 4182
**********
from January 2001 contact also:
The Regius Chair of Botany
Institute of Biomedical and Life Sciences
Bower Building
University of Glasgow
Glasgow G12 8QQ

email:  m.blatt at bio.gla.ac.uk
phone: (+44 (0)141) 330 4771
fax: (+44 (0)141) 330 4447
mobile: 0789 907 4182


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