Post-doc positions & Tech position

Mannie Liscum LiscumM at missouri.edu
Thu Jun 14 13:51:52 EST 2001


<x-flowed>POSTDOCTORAL POSITION and TECHNICIAN POSITION

University of Missouri
Division of Biological Sciences
Columbia, MO

Two functional genomics positions (one postdoctoral and one
technician) are currently available to study the expression and
function of all members of the NPH3/RPT2 family of Arabidopsis. NPH3
is a novel protein essential for phototropism in low light conditions
that has been found to interact with the phototropin 1 (phot1)
photoreceptor in vitro and in yeast (Motchoulski and Liscum, 1999,
Science 286:961-964), while RPT2 has been found to function in
phototropic signaling under high light conditions (Sakai et al.,
2000, Plant Cell 12: 225-236) and presumably interacts with the high
light-responsive phot2 receptor. The current working hypothesis for
NPH3 and RPT2 function in early phototropic signaling is that these
proteins act as modular scaffold proteins to recruit or activate
enzymatic components of the transduction chains mediating low and
high fluence rate phototropic responses, respectively (Liscum and
Stowe-Evans, 2000).  By extension we hypothesize that additional
members of the NPH3/RPT2 family also act as molecular scaffolds but
in a (potentially) wide variety of biotic and abiotic responses.

Three major areas of research are underway: 1) To determine the
pattern(s) of expression (both mRNA and protein) for each member of
the NPH3/RPT2 family, 2) to isolate both loss- and gain-of-function
alleles for each member of the NPH3/RPT2 family, and 3) to use these
mutants along with expression data to determine biological functions
for each member of the family.  For more information see our
preliminary project web page:
http://www.biosci.missouri.edu/liscum/NPH3-RPT2family.html.

Applicants for the postdoctoral position should have a PhD in
biology/biochemistry with experience in plant molecular biology.
Experience with protein chemistry is certainly a bonus. Interested
candidates should send a cover letter, CV, and names/addresses of
three references to Mannie Liscum, preferably by email
(liscumm at missouri.edu).

Applicants for the technician position should have a BS/MS in
biology/plant biology with experience in plant molecular biology, and
preferably experience with database curation/management.  Interested
candidates should contact Mannie Liscum via email
(liscume at missouri.edu) for information on where to send application
(tech positions are routed through the MU personnel office).

------

POSTDOCTORAL POSITION

University of Missouri
Division of Biological Sciences
Columbia, MO

A postdoctoral position is currently available to study the NPH3
protein of Arabidopsis. NPH3 is a novel protein essential for
phototropism in low light conditions that has been found to interact
with the phototropin 1 (phot1) photoreceptor in vitro and in yeast
(Motchoulski and Liscum, 1999, Science 286:961-964; also see
http://www.biosci.missouri.edu/liscum/LiscumLabPage.html for more
information about the lab). Current research includes
structure-function studies of the NPH3 protein. Large numbers of nph3
mutants are, and will be, being generated by directed and random
mutagenesis and then assayed via transgenic complementation (or
partial/non-complementation) of known nph3-null mutants. In addition
we will use BRET (Bioluminescence Resonance Energy Transfer)
technology being developed by Albrecht von Arnim (U Tenn) and Carl
Johnson (Vaderbuilt U) to examine phot1-NPH3 interaction in planta.
These studies together with other traditional biochemical and genetic
approaches are being used to elucidate the biochemical function(s) of
the NPH3 protein.

Applicants for this position should have a PhD in
biology/biochemistry with experience in plant molecular biology.
Experience with protein chemistry is certainly a bonus. Interested
candidates should send a cover letter, CV, and names/addresses of
three references to Mannie Liscum, preferably by email
(liscumm at missouri.edu).
------

I will be available at the Arabidopsis meeting in Madison (June
23-27) to discuss these opportunities with interested candidates.
Please email me (liscume at missouri.edu) if you wish to get together.

The University of Missouri is an equal opportunity employer.


-- 

Cheers,
Mannie

*******************************************************************
Mannie Liscum
Associate Professor
Division of Biological Sciences
108C Tucker Hall
University of Missouri
Columbia, MO 65211

email: liscumm at missouri.edu
office:573-882-2672; 108C Tucker Hall
lab:573-882-2675 ;108 Tucker Hall
fax: 573-882-0123
web page: http://www.biosci.missouri.edu/liscum/LiscumLabPage.html

"The ending is just the beginning. The closer you get to the meaning,
the sooner you'll find that you're dreaming"....RJD
*******************************************************************

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