postdoctoral position at Brown University

Alison Delong Alison_Delong at brown.edu
Mon Nov 12 13:39:09 EST 2001


POSTDOCTORAL RESEARCHER POSITION
REGULATION OF PROTEIN PHOSPHATASE ACTIVITY BY THE RCN1 PROTEIN

Laboratory of Alison DeLong
Brown University, Providence Rhode Island

A postdoctoral position is available for a period of up to three years
to study the role of the Arabidopsis RCN1 gene product in regulating the
activity of protein phosphatase 2A (PP2A).  PP2A is a highly conserved
heteromeric serine/threonine phosphatase that has been implicated in a
wide array of biological processes in various eukaryotes.  The RCN1 gene
encodes a regulatory A subunit of PP2A, and loss of RCN1 function leads
to reduced PP2A activity in vivo and in vitro.  Plants carrying the rcn1
mutation exhibit defects in differential cell elongation responses such
as gravitropism.  These growth defects are correlated with altered auxin
transport in rcn1 seedlings, and in seedlings treated with phosphatase
inhibitors, implicating PP2A activity in the regulation of auxin
transport.  Currently we seek to define the factors that specify RCN1
function and we will further characterize the role of RCN1 in regulating
auxin transport.

For additional information see
      Muday, G.K. and A. DeLong (2001) Polar auxin transport:
Controlling where and how much. Trends in Plant Science 6: 535-542.
      Rashotte, A. M., A. DeLong and G. K. Muday (2001)  Genetic and
chemical reductions in protein phosphatase activity alter auxin
transport, gravity response and lateral root growth. The Plant Cell. 13:
1683-1697.
      Deruere, J., K. Jackson, C. Garbers, D. Soll and A. DeLong (1999)
The RCN1-encoded A subunit of protein phosphatase 2A increases
phosphatase activity in vivo. The Plant Journal 20: 389-399.
      Garbers, C., A. DeLong, J. Deruere, P. Bernasconi and D. Soll
(1996)  A mutation in Protein Phosphatase 2A Regulatory Subunit A
Affects Auxin Transport in Arabidopsis. EMBO J. 15: 2115-2124.
      http://biomed.brown.edu/Faculty/D/delonga.html

Candidates must have a strong background in molecular genetics and/or
biochemistry.  To apply, please send your current CV, a letter outlining
your research interests and accomplishments, and arrange to have three
letters of reference sent directly to Prof. Alison DeLong; Dept. of
Molecular Biology, Cell Biology and Biochemistry; Brown University;
Providence RI  02912; TEL 401-863-3888; FAX  401-863-2421;
Alison_DeLong at Brown.edu



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