Postdoctoral position available

Nobody nobody at
Mon May 13 07:16:58 EST 2002


Ref: R9447
Postdoctoral Research Associate:
Plant Molecular and Cell Biology
R&AIA =A317,626 to =A326,491 pa
Available for up to 3 years

Project: Dissecting the cell biology of plastid division

A 3-year, BBSRC-funded postdoctoral position is available to study 
the cell biology of plastid division in plants.

Plastids are essential integral organelles of plant cells and 
probably the most important aspect of maintaining plastid 
functionality is the control and execution of plastid division. 
Plastids divide by binary fission from existing plastids in the 
cytoplasm, however, very little is known about the process and few 
components have to date been isolated. By comparing the bacterial 
division apparatus with the Arabidopsis nuclear genome we are 
starting to gain some initial insight into the plastid division 
process in plants. In bacteria, division is initiated by the FtsZ 
proteins (Z-ring formation) and FtsZ-deficiency in Arabidopsis 
results in mesophyll cells containing very few chloroplasts (as few 
as one) compared to wild-type (~100 chloroplasts). Correct placement 
of the bacterial Z-ring requires MinC, MinD, and MinE. MinC acts as a 
division inhibitor preventing FtsZ ring formation at locations other 
than midcell by direct interaction with FtsZ to prevent 
polymerisation. The activity of MinC is dependent on Mi
We are interested in dissecting the cell biology of plastid division 
using a combination of  proteomics, advanced cell biology 
(multi-channel GFP,YFP,CFP time-lapse 3D-imaging) and global 
microarray analysis.

The M=AFller laboratory is newly refurbished and houses a new 
epifluorescence inverted microscope with computer-interfaced 
multi-channel filters for simultaneous GFP, YFP and CFP imaging in 
3D/4D. This will be used for intraplastidic localisation studies.

The project is technically and intellectually demanding and therefore 
requires a postdoctoral assistant with experience in aspects of plant 
physiology, molecular and cell biology, and preferably in 
protein-protein interaction studies.

Informal enquiries to Dr. Simon Geir M=AFller (Tel: (0116) 252 5302; 
email:sgm5 at
Applications should be made on the form provided, forwarded to reach 
the Personnel Office (Appointments) not later than 7 June 2002.

University of Leicester
University Road
Leicester LE1 7RH

Tel:  +44 (0) 116 252 5114
=46ax:  +44 (0) 116 252 5140
Email: personnel at

Dr. Simon Geir M=AFller
Department of Biology
=46aculty of Medicine & Biological Sciences
University of Leicester
Leicester LE1 7RT, UK
Tel: +44 (0)116 252 5302 (office): 3339 (lab)
=46ax: +44 (0116) 252 3330



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