POSTDOCTORAL RESEARCH POSITION

Nobody nobody at hgmp.mrc.ac.uk
Mon Dec 1 09:58:33 EST 2003


POSTDOCTORAL RESEARCH POSITION
REGULATION OF PROTEIN PHOSPHATASE 2A ACTIVITY

Laboratory of Alison DeLong
Brown University, Providence Rhode Island

A postdoctoral position is available for a period of up to three 
years to study the roles of the Arabidopsis regulatory A subunits in 
controlling the activity of protein phosphatase 2A (PP2A).  PP2A is a 
highly conserved heteromeric serine/threonine phosphatase that has 
been implicated in a wide array of biological processes in various 
eukaryotes.  The RCN1 gene encodes a regulatory A subunit of PP2A, 
and loss of RCN1 function leads to reduced PP2A activity, altered 
auxin transport, and defects in differential cell elongation 
responses.  RCN1 is one constituent of a three-member gene family, 
and we are analyzing the roles of RCN1 and the two other regulatory A 
subunit isoforms.  Currently we seek to define the factors that 
specify the functions of each A subunit isoform, and we will further 
characterize the role of RCN1 in regulating auxin transport.

=46or additional information see

			DeLong, A., K. Mockaitis and S. Christensen 
(2002)  Protein phosphorylation in the delivery of and response to 
auxin signals. Plant Mol Biol. 49:285-303
	Rashotte, A. M., A. DeLong and G. K. Muday (2001)  Genetic 
and chemical reductions in protein phosphatase activity alter auxin 
transport, gravity response and lateral root growth. The Plant Cell. 
13: 1683-1697.
	Deru=E8re, J., K. Jackson, C. Garbers, D. S=F6ll and A. DeLong 
(1999)  The RCN1-encoded A subunit of protein phosphatase 2A 
increases phosphatase activity in vivo. The Plant Journal 20: 389-399.
	Garbers, C., A. DeLong, J. Deru=E8re, P. Bernasconi and D. S=F6ll 
(1996)  A mutation in Protein Phosphatase 2A Regulatory Subunit A 
Affects Auxin Transport in Arabidopsis. EMBO J. 15: 2115-2124.
	http://biomed.brown.edu/Faculty/D/delonga.html
Candidates must have a strong background in molecular genetics and/or 
biochemistry.  To apply, please send your current CV, a letter 
outlining your research interests and accomplishments, and arrange to 
have three letters of reference sent directly to Prof. Alison DeLong; 
Dept. of Molecular Biology, Cell Biology and Biochemistry; Brown 
University; Providence RI  02912; TEL 401-863-3888; FAX  401-863-2421.



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