Postdoctoral opportunities

Iris Meier meier.56 at
Sun Mar 14 14:51:11 EST 2004


Two NSF-funded postdoctoral positions are available at the Plant 
Biotechnology Center, Ohio State University, Columbus, Ohio. The 
first position is for an individual to study the function of nuclear 
coiled-coil proteins in Arabidopsis. In yeast and animals, long 
coiled-coil domains are involved in the functional association of 
centromers, centrosomes, the nuclear matrix, and chromatin. In 
contrast, only a handful of long coiled-coil proteins have been 
identified from plants. We have recently used a bioinformatics 
approach to identify all long coiled-coil proteins in the Arabidopsis 
ORFeome and have now mined these data for proteins potentially 
involved in nuclear organization. We will use a combination of 
reverse genetics, biochemistry, and proteomics to investigate the 
function of these proteins. (Rose et al. (2004) Genome-wide 
Identification of Arabidopsis Coiled-coil Proteins and Establishment 
of the ARABI-COIL Database. Plant Physiol. 134, 927-939; Calikowsky 
et al. (2003) A Proteomic Study of the Arabidopsis Nuclear Matrix. J. 
Cell. Biochem. 90, 361-378).

The second position will be in the area of spatial organization of 
Ran signaling in Arabidopsis. An emerging theme in signal 
transduction research is how the different pathways of signaling 
events are both separated and coordinated in a temporal and spatial 
manner in the living cell. RanGAP is an accessory protein of Ran 
signaling, which functions in nuclear transport, mitotic spindle 
assembly, and post-mitotic nuclear assembly. We have found that plant 
RanGAP is spatially positioned in interphase and during mitosis by a 
different mechanism than animal RanGAP. Our goal is now to understand 
the molecular mechanism, biological function, and evolutionary 
history of this subcellular targeting mechanism that may be unique to 
the plant kingdom. (Rose, A. and Meier, I. (2001). A domain unique to 
plant RanGAP is responsible for its targeting to the plant nuclear 
rim. Proc. Natl. Acad. Sci. U.S.A. 98, 15377-15382; Meier, I. (2000). 
A novel link between Ran signal transduction and nuclear envelope 
proteins in plants. Plant Phys. 124, 1507-1510).

Both positions are available immediately and are competitively 
funded. Successful candidates will be highly motivated and creative 
individuals, will have experience in molecular biology, biochemistry, 
or cell biology, and will have published in internationally 
recognized journals.

If you are interested in these opportunities, please send by e-mail a 
CV with a list of publications, a statement of research experience 
and interests, and contact information for three persons who can 
provide letters of recommendation. Please mention in your letter 
whether you are specifically interested in one of the research areas.

Iris Meier, Ph.D.
Associate Professor
Plant Biotechnology Center and Department of Plant Biology
The Ohio State University
244 Rightmire Hall, 1060 Carmack Road
Columbus, OH 43210
PHONE: (614) 292 8323, FAX: (614) 292 5379, email: meier.56 at

More information about the Arab-gen mailing list