Postdoctoral research position

Nilgun Tumer tumer at
Thu Oct 7 17:13:58 EST 2004

Postdoctoral Research Position

Rutgers University

New Brunswick, NJ

   A postdoctoral research associate position is available at the Biotech
Center at Cook College/Rutgers University to study programmed cell death
induced by ribosome inactivating proteins (RIPs).  RIPs like pokeweed
antiviral protein (PAP) and ricin A chain (RTA) depurinate the highly
conserved sarcin/ricin loop of the large rRNA, inhibit translation and
cause cell death.  We showed that PAP binds to the cap structure on
cellular and viral RNAs and inhibits translation in vitro by depurinating
these RNAs downstream of the cap structure (Hudak et al. 2002 RNA,
8:1148-1159).  PAP regulates its expression by destabilizing its own mRNA
in vivo (Parikh et al., 2002 Jour. Biol. Chem.
277:41428-41437).  Cytotoxicity of PAP can be dissociated from depurination
of the sarcin/ricin loop (Hudak et al. 2004 Nucleic Acids Res.
32:4244-4256).  A postdoctoral research associate is sought for an NIH
funded position to characterize the relationship between the interaction of
RTA with the ribosome and its cellular toxicity in yeast and in mammalian
cells. Qualifications include a Ph.D. in a related field, experience with
RNA biochemistry and molecular biology and demonstration of an active
publication record.  Please send CV and the names and addresses of three
references to Dr. Nilgun Tumer, Biotech Center, Foran Hall, Cook College,
Rutgers University, New Brunswick, NJ 08901-8520.

email:<mailto:tumer at>tumer at,


Dr. Nilgun E. Tumer                                     Tel:  732-932-8165X215
Professor                                               Fax: 732-932-6535

Biotechnology Center
Rutgers, The State University of New Jersey
Cook College
Foran Hall
59 Dudley Road
New Brunswick, NJ 08901-8520


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