using GOtoolBox to analyse sets of Arabidopsis genes

Nobody nobody at hgmp.mrc.ac.uk
Fri Jan 21 09:58:18 EST 2005


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  Dear colleagues,


  This short mail to inform the Arabidopsis community of the
availability of GOToolBox, a series of programs using Gene ontology
that we published recently in Genome biology
(http://www.biomedcentral.com/content/pdf/gb-2004-5-12-r101.pdf).

  GOToolBox can be useful to analyse groups of genes derived from
microarrays,Chromatin-Immunoprecipitations, from the analysis of
protein-protein (two-hybrid), protein_DNA and/or genetic networks,
=2E...

The programs from GOToolBox are directly accessible through a Web
site described in the article.

  GOToolBox performs five main tasks:

  - gene dataset creation,
  - selection and fitting of GO terms at a given ontology level (GO-Diet),
  - statistical analysis of GO terms associated with gene sets
(GO-Stats) in order to find over- or under-represented terms,
  - GO-based gene clustering (GO-Proxy) allowing to find sub-groups of
functionnally related genes within a gene set,
  - gene retrieval based on GO annotation similarity (GO-Family) in
one or several species.

  Other developments are presently on their way.

  At the moment, GOToolBox supports analyses of GO terms for six species :
Yeast (Sc), Arabidopsis, Drosophila, nematode, mouse and humans.



  For the authors,

  David Martin and Bernard Jacq

Bernard Jacq
LGPD-IBDM
Parc Scientifique de luminy
13288 Marseille Cedex 9

tel (33) 04 91 82 94 25
fax (33) 04 91 82 06 82


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