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A post-doctoral position is available to study chromatin remodeling in
the laboratory of Dr. Doris Wagner in the Department of Biology at the
University of Pennsylvania in Philadelphia.
SWI/SNF chromatin remodeling ATPases are important transcriptional
co-regulators in multicellular eukaryotes. The precise role of these
proteins in the organism has remained poorly understood because null
mutants in most are embryonic lethal. Recently, we isolated viable
SWI/SNF ATPase null mutants in Arabidopsis. Our studies revealed that
these chromatin remodelers regulate multiple developmental pathways. In
addition we observed a remarkable degree of functional specificity for
SWI/SNF chromatin remodeling in individual developmental processes.
This postdoctoral position is to extend these studies and to address the
following two central questions:
what are the developmentally important targets of SWI/SNF ATPases in
what is the precise mechanism by which SWI/SNF ATPases control their
target genes in vivo?
The qualified candidate is expected to use and develop state-of-the art
forward/reverse genetic and genomic approaches to address these
questions. Individuals with experience in these approaches are strongly
encouraged to apply.
To apply please send a CV and three reference letters via email to
wagnerdo At sas.upenn.edu.
Department of Biology, 201 Mudd
University of Pennsylvania wagnerdo At sas.upenn.edu
415 S. University Ave Phone: (215) 898-0483
Philadelphia, PA 19104-6018 Fax: (215) 898-8780