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[Arabidopsis] postdoctoral position in chromatin remodeling

Doris Wagner via arab-gen%40net.bio.net (by wagnerdo At sas.upenn.edu)
Tue Nov 14 13:34:21 EST 2006

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A post-doctoral position is available to study chromatin remodeling in 
the laboratory of Dr. Doris Wagner in the Department of Biology at the 
University of Pennsylvania in Philadelphia.

SWI/SNF chromatin remodeling ATPases are important transcriptional 
co-regulators in multicellular eukaryotes. The precise role of these 
proteins in the organism has remained poorly understood because null 
mutants in most are embryonic lethal. Recently, we isolated viable 
SWI/SNF ATPase null mutants in Arabidopsis. Our studies revealed that 
these chromatin remodelers regulate multiple developmental pathways. In 
addition we observed a remarkable degree of functional specificity for 
SWI/SNF chromatin remodeling in individual developmental processes.

This postdoctoral position is to extend these studies and to address the 
following two central questions:
• what are the developmentally important targets of SWI/SNF ATPases in 
the organism?
• what is the precise mechanism by which SWI/SNF ATPases control their 
target genes in vivo?
The qualified candidate is expected to use and develop state-of-the art 
forward/reverse genetic and genomic approaches to address these 
questions. Individuals with experience in these approaches are strongly 
encouraged to apply.

To apply please send a CV and three reference letters via email to 
wagnerdo At sas.upenn.edu.

Doris Wagner
Department of Biology, 201 Mudd
University of Pennsylvania 			wagnerdo At sas.upenn.edu
415 S. University Ave				Phone: (215) 898-0483
Philadelphia, PA 19104-6018			Fax: (215) 898-8780

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