[Arabidopsis] Postdoctoral Researcher Position available
Huw H. Rees
(by reeshh from liverpool.ac.uk)
Wed Apr 4 10:16:37 EST 2007
Postdoctoral Researcher (Molecular Biology/Post-genome Technologies)
Applications are invited for a Postdoctoral Researcher to work on the
identification, cloning and heterologous expression of the genes
encoding the enzymes catalysing the four steps of the important
pathway of plant sterol dealkylation to cholesterol in insects. The
project will involve a range of post-genomic technologies, including
bioinformatics and proteomics.
Most species of invertebrate animals cannot synthesise sterols (e.g.
cholesterol) and rely on a dietary source. Plant pest insects and
plant parasitic nematodes obtain their sterols (e.g. sitosterol) from
the plants. Without chemical modification, these plant sterols cannot
satisfy the sterol requirement for normal growth of the
invertebrates, which have a specific need for a cholesterol-like
sterol. Thus, such organisms must dealkylate plant sterols (e.g.
sitosterol, C29) to yield cholesterol (C27). Most studies of the
dealkylation pathway have been undertaken in plant-pest insects, as
well as in the model nematode species, Caernorhabditis elegans. The
conversion (dealkylation) of sitosterol to cholesterol occurs via a
four-step pathway, which has been demonstrated in the microsomal
membranes in insect midgut. The current project aims to clone and
characterise the genes encoding the four enzymes catalysing the
dealkylation reactions from the silkworm, Bombyx mori and to model
You will join a particularly active multi-disciplinary laboratory
within a modern, well equipped building, that incorporates Core
Facilities in post-genomic technologies, including Non-Invasive Cell
Imaging, Functional Proteomics, Transcriptomics, Transgenic Plants
and Structural Biology (biological NMR).
You should have (or be about to obtain) a Ph.D. in an appropriate
biological science and experience of molecular biology is essential.
The post is funded by The Leverhulme Trust for up to two years.
Informal enquiries prior to application may be made to Prof H H Rees
(reeshh from liv.ac.uk).
For full details of the post, or to request an application pack, visit
www.liv.ac.uk/university/jobs.html or e-mail jobs from liv.ac.uk ; Tel
0151 794 2210 (24 hr answerphone). Please quote Ref: B/991 in all
Professor of Biochemistry
School of Biological Sciences
University of Liverpool
The Biosciences Building
Tel: (44) 151-795-4465
Tel: (44) 151-795-4401 (Secretary)
Fax: (44) 151-795-4406
E-mail: reeshh from liv.ac.uk
Liverpool, European Capital of Culture, 2008
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