[Arabidopsis] (no subject)

caroline dean (JIC) via arab-gen%40net.bio.net (by Caroline.Dean from bbsrc.ac.uk)
Fri Feb 23 11:35:45 EST 2007

One 3 yr post-doctoral position (post 1655, salary range ~24-27K) is available in Caroline Dean's group at the John Innes Centre, Norwich, UK starting immediately. This is a BBSRC-funded project entitled 'Natural variation in vernalization response of Arabidopsis accessions'. The plan is to exploit our understanding of the molecular basis of vernalization in Arabidopsis (http://www.jic.ac.uk/staff/caroline-dean/index.htm) and the adaptive importance of this trait and combine a molecular, evolutionary and ecological study to understand how Arabidopsis accessions have spread to very different parts of Europe. Analysis of flowering in Arabidopsis accessions provides a rare opportunity to link mechanistic understanding of a complex trait with an understanding of the fitness consequences of different alleles and thus distribution within the population. The specific aims (for two post-doctoral fellows, one already appointed) will be to 
1) fully define the molecular variation underpinning the natural variation in accessions carefully selected to represent a range of vernalization responses 
2) to investigate how that molecular variation has resulted in changed flowering phenotype. 

We will also analyse the range of allelic variation and pattern of polymorphism in the loci involved to understand their molecular evolution and determine the fitness consequences of that variation in different environments to investigate the selective forces that have resulted in the phenotypic variability in natural populations. This will be in collaboration with Dr Magnus Nordborg (U. S. California) and Dr Johanna Schmitt (Brown U. RI).

If interested please email to caroline.dean from bbsrc.ac.uk.

Recent relevant publications: 
Bastow R, Mylne J. S., Lister C., Lippman Z., Martienssen R.A. & Dean C. (2004) Vernalization requires epigenetic silencing of FLC by histone methylation. Nature 427, 164-167.

Shindo, C., Aranzana, M.J., Lister, C., Baxter, C., Nicholls, C., Nordborg, M., Dean, C. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time in Arabidopsis accessions Plant Physiol. 138, 1163-73

Aranzana, M, Kim, S., Zhao, K., Bakker E., Horton M., Jakob K., Lister C., Molitor J., Shindo C., Tang C., Toomajian C., Traw B., Zheng H., Bergelson J., Dean C., Marjoram P., Nordborg M. (2005) Genome-wide association mapping in Arabidopsis thaliana identifies previously known genes responsible for variation in flowering time and pathogen resistance PLoS Genetics Nov 11;1(5):e60

Toomajian, C., Hu, T., Aranzana, MJ., Lister, C., Tang, C., Zheng, H., Calíbrese, P., Dean, C., Nordborg, M. (2005) A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome PLoS Biology May;4(5):e137

Shindo C, Lister C, Crevillen P, Nordborg M, Dean C. (2006) Variation in the epigenetic silencing of FLC contributes to natural variation in Arabidopsis vernalization response. Genes Dev 20(22):3079-83

Greb T, Mylne JS, Crevillen P, Geraldo N, An H, Gendall AR, Dean C. (2007) The PHD Finger Protein VRN5 Functions in the Epigenetic Silencing of Arabidopsis FLC. Curr Biol. 17, 73-78.

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