[Arabidopsis] Post Doctoral Positions in Plant Molecular Biology

Mohan Singh via arab-gen%40net.bio.net (by mohan from unimelb.edu.au)
Sun Sep 21 08:57:50 EST 2008


Expressions of interest are sought to fill postdoctoral positions within the
Plant Molecular Biology and Biotechnology group, at the Melbourne School of
Land and Environment at The University of Melbourne, highest ranked Research
University in Australia.   We are interested in recruiting highly motivated
individuals with a desire to succeed and contribute to the internationally
competitive research activities of the laboratory focussing on molecular
mechanisms of differentiation and cell specific gene regulation during
meristem development, floral transition and reproductive differentiation. A
brief description of research projects is provided below.
MicroRNAs and Epigenetic Regulation of Meristem Development
MicroRNAs (miRNAs) are small non-coding RNAs that regulate expression of
many genes.  We have recently discovered a network of shoot apical meristem
specific miRNAs. These include novel plant miRNAs being reported for the
first time.  The postdoctoral research project will involve investigation of
role of these novel miRNAs in meristem development and floral transition
using computational and experimental tools.  The experimental approach will
include expression profiling of individual miRNAs through gel blots,
microarrays, in situ localizations combined with gain-and loss-of-function
studies in transgenic plants.
Molecular Control of Stem Cell Maintenance in Plants
Shoot apical meristems (SAMs) provide niches for self-sustaining groups of
stem cells that play a critical role in plant development being founder
cells of all aerial plant parts.  Maintenance of these stem cells is thus
essential for repetitive organ initiation throughout plant lifecycle.  Using
high throughput gene expression profiling technologies we have identified
subset of novel genes that are differentially expressed in shoot apical
meristem of pea and soybeans.  The postdoctoral appointee will participate
in a project addressing developmental role of these genes.  The approaches
will include laser capture microdissection, mutant analyses, in situ
hybridisations, and reporter gene expression and gain-and loss-of-function
studies in transgenic plants.
Male Germ Line Development and Fertilization in Flowering Plants
Unlike animals where germ line cells diverge from somatic cells during early
embryo development the plant germ lineages initiate late in development at
flowering stage.  The male germline in plants begins with an asymmetric
division, after which one of the resulting cells, the generative cell,
divides symmetrically to produce two sperm cells. Research from our
laboratory has revealed that the male germ line cells show transcriptional
repertoire that is highly divergent from other reproductive and somatic
cells.  The post-doctoral appointee will participate in a project focusing
on role of cell specific genes and nature of associated regulatory
mechanisms. Potential approaches include Potential approaches include
DNA-protein interaction analyses, chromatin immunoprecipitation (ChiP), gene
knockout in transgenic plants, proteome and methylome analysis,
live imaging of fertilization events.
Applicants should possess a PhD, together with relevant experience in one or
more fields of functional genomics, molecular genetics and cell biology and
be able to provide evidence of proven research productivity in the form of
publications in refereed journals. Candidates should also be experienced in
general molecular biology techniques and ideally have expertise in one or
more of following techniques/approaches; protein-DNA interactions,
protein-protein interactions, ChIP, protein biochemistry and bioinformatics.
The positions are being offered at Research Fellow ( Level A) position with
salary range of $63,451-$68,109 p.a.  Candidates with exceptional
achievements can be considered for appointment at a higher salary level.
Applications close on 17 th October 2008.  For further details contact:
Professor Prem L Bhalla, tel. +61 3 8344 9651, email premlb from unimelb.edu.au
or Professor Mohan B Singh, tel. +61 3 8344 5051, email mohan from unimelb.edu.au

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