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[Arabidopsis] post-doc positions in plant circadian biology, UC Davis

Stacey Harmer via arab-gen%40net.bio.net (by slharmer from ucdavis.edu)
Sat Jun 29 20:33:32 EST 2013

Post-doctoral Research Positions at UC Davis

Two post-doctoral positions in circadian biology are available in the =
Department of Plant Biology at UC Davis, starting October 1, 2013 or =
upon agreement.

The NIH-sponsored project focuses on understanding the molecular basis =
of circadian rhythms in the complex eukaryote Arabidopsis thaliana.  =
Although the Arabidopsis circadian clock influences diverse stress, =
developmental, and growth pathways, its molecular nature is incompletely =
understood.  In particular, how the clock regulates expression of nearly =
one-third of the transcriptome so that target genes are expressed at =
specific times of the day and night is largely unknown.  Two =
post-doctoral fellows are sought for two related projects: investigating =
the roles of the RVE family transcription factors and of a novel =
chromatin regulatory protein within the circadian system.=20

We recently identified a small family of transcription factors (the =
RVEs) as essential components of the plant clock (Rawat et al, 2011; Hsu =
et al, 2013).  These Myb-like factors promote the expression of =
evening-phased target genes, acting in opposition to the repressors CCA1 =
and LHY to ensure the clock runs with a close to 24 hour rhythm.  Among =
other experiments, the successful post-doc applicant will carry out =
competitive chromatin immunoprecipitation experiments to define the =
genome-wide binding dynamics of, and competitive interactions between, =
these antagonistic transcription factors.  He/she will then correlate =
these chromatin binding dyamics with the circadian patterns of =
expression of target genes.  These studies will allow us to define how =
the binding parameters of antagonistic transcription factors to =
promoters shape the dynamic control of gene expression in vivo.

The second project focuses on XCT, a gene originally identified as a =
circadian mutant (Martin-Tryon and Harmer, 2008).  Although mutation of =
XCT affects multiple processes, the circadian clock is particularly =
sensitive to changes in XCT function.  We have recently determined that =
XCT encodes a chromatin regulatory protein with conserved function =
across eukaryotes (Anver et al, submitted; Ellison et al, submitted).  =
The successful post-doc applicant will use genomic, genetic, and =
biochemical approaches to study the mode of action of XCT and how it =
affects the clock.

Successful applicants will have received their PhD degrees within the =
past three years, have strong publication records, be familiar with =
standard molecular techniques, and have a keen interest in circadian =
biology; familiarity with genome-wide analytical methods would be highly =
advantageous.  A strong record of publication will be the major =
criterion for screening applicants.

This work will be performed at the Dept. of Plant Biology at the =
University of California, Davis, under the supervision of Dr. Stacey =
Harmer.  With over 100 plant-focused research groups and a strong =
program in the biological sciences in many model systems, UC Davis =
provides an excellent environment for fundamental studies in plant =
biology.  Davis is a pleasant college town located in the northern =
Central Valley of California.  It is 20 minutes from the state capital =
(Sacramento), and 1hr 20=92 from San Francisco.

Applications should include a CV and three letters of reference and be =
sent to:

 Dr. Stacey Harmer

slharmer from ucdavis.edu


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