The laboratory of Brad Day at Michigan State University is seeking to fill multiple postdoctoral positions to work on recently funded National Institutes of Health (NIH) and the National Science Foundation (NSF). In brief, the recently funded projects will focus in the areas of stomatal actin signaling (NSF) and nucleocytoplasmic control of actin filament dynamics during immune activation (NIH). The research projects will:
NIH: Couple cell biology, pathology, and whole-transcriptome analyses to characterize the function of actin-associated regulons using pathogen infection. The goal of this work is to define and characterize the gene networks that are 1) regulated by changes in ADF/actin organization and localization; 2) regulated by immune kinases, including pathogen targeting of these kinases; and 3) required for immunity and cell death in response to pathogen targeting of the host actin cytoskeleton.
NSF: Investigate how the actin cytoskeleton functions to transition from homeostatic surveillance to roles that regulate immune signaling. Our recent work demonstrates that Pseudomonas targets the host actin cytoskeleton through multiple, independent mechanisms (e.g., Porter et al., 2012; Henty-Ridilla et al., 2013, Shimono et al., 2016a,b). This project will define the interactions between actin, stomatal immunity, abiotic stress, and hormone signaling.
Qualifications: The individual must have a Ph.D. in molecular biology, genetics, biochemistry, or a related field, training in cell biology, mRNA expression analysis, and other molecular biology techniques, and a publication record demonstrating his/her research competence.
Preferred Qualifications: The individual should have a demonstrated track record of successful performance as an independent researcher and in a team-environment. Research experience with plant systems, particularly Arabidopsis, is highly desirable. Research experience in plant-microbe interactions and cell biology (i.e., confocal microscopy) is also desirable. The primary responsibility of the incumbent will be wet-lab research; however, it is expected that some dry-lab research experience, such as gene expression profiling, will be needed.
Summary of Position:
The main responsibility of the individual is to conduct wet-lab research in plant-pathogen interactions, specifically in the area of pathogen manipulation of host cytoskeletal organization. In short, the project has two primary foci, one being to elucidate the role of the actin cytoskeleton as a immune signaling platform, and the other being to define how pathogen manipulate this signaling process. This project is currently support by grants from the NSF and NIH. The individual may be involved in dry-lab research part of the projects, dependent on his/her interest and proficiency. Other responsibilities include working together with other lab members to maintain and improve lab environment, including organizing research material stocks, and mentoring and supervising undergraduate/graduate student researchers.
Essential and Other Functions:
Conduct wet-lab research in plant-pathogen interactions
The individual will design and perform experiments and interpret the experimental results. The individual will communicate the research-related issues with lab members. It is expected that the individual will generate data sufficient for publication in peer-reviewed journals, as well as, when appropriate, attend scientific conferences to present their data. The experimental techniques for the research include cell biology, molecular biology/genetics techniques, plant husbandry, plant transformation, pathogen assays on plants, and gene expression analyses.
How To Apply
To apply, please send a cover letter, CV, and statement of research experience and future interests to Brad Day, bday from msu.edu<mailto:bday from msu.edu>. Please also include the names of 3 individuals that can be contacted for letters of recommendation.
About the Lab: The Day lab is housed on the 4th floor of the molecular plant science research facility on the Michigan State University (MSU) Campus. We share approximately 15,000 square feet of research and office space with the laboratories of Drs. Sheng Yang He, Gregg Howe, and Mike Thomashow, with ample bench space for 40 researchers, specialized research instrumentation, office and meeting spaces, computer and reading rooms, etc. http://msudaylab.org/
Associate Chair for Research
Michigan State University
Plant, Soil and Microbial Sciences
4200 Molecular Plant Science Building
1066 Bogue Street
East Lansing, MI 48824-6254