Life Sciences News Update

Bio.com / Bio Online newsletter at bio.com
Tue Apr 9 17:58:34 EST 2002

Bio.com Life Sciences News Update
April 10, 2002

Produced by Bio Online®
The Life Sciences Portal(tm)
www.bio.com | www.bioprotocol.com



1.  Science News: “Brain Center Searches for Patterns”
2.  InFocus:  “Structural Genomics” 
3.  Bio.com Job Fair:  May 4, 2002 @ Oakland Marriott Convention Center
4.  Jobs of the Week:  “Research Associate” and others
5.  Market Research:  “Antisense Therapeutics: The Emerging World Market”
6.  Featured Software:  “Array Designer 2” and others

Sponsored by:  

Join Biotech and Pharma executives, financial professionals and BIO
President and keynote speaker Carl Feldbaum at TWST’s second Biotechnology
Industry Conference on Thursday, May 9, 2002 in New York City at The
Princeton Club. CEOs from Allos Therapeutics, AVANT Immunotherapeutics,
Dendreon, Immerge Biotherapeutics, Incara Pharmaceuticals, Incyte Genomics,
Infigen, SuperGen, VaxGen; representatives from the Johnson & Johnson,
Pfizer, PPL Therapeutics, Vertex Pharmaceuticals and OSI Pharmaceuticals;
and top financial executives from JP Morgan, Perseus Soros Biopharmaceutical
Fund, Federated Kaufmann Fund, Orbimed Advisors and SG Cowen will attend.
For more information visit http://www.twst.com/conferences/ or call 
Joanna Schmitcke at (212) 952-7400 ext. 136 and mention Bio.com.


-Protein That Halts Huntington's Disease Found
A protein developed in the laboratory halts the progression of Huntington's
disease in fruit flies, a study by UC Irvine and MIT has found. The study is
the first to identify a man-made protein that can stop the development of
the disease, and it may help researchers find effective ways to use gene
therapy to prevent--or halt--the disease.

-Search-and-Destroy Weapon Targets Cancer
By combining a chemotherapy drug with a sugar that normally helps cancer
move through the human body, University of Utah researchers developed a new
medication to track down, invade and destroy tumor cells as they spread or

-Vitamin Megadoses May Help Treat Metabolic Diseases
Linus Pauling's claim that megadoses of vitamin C can prevent colds remains
unproven, yet high doses of some vitamins could play a big role in the
treatment of disease and perhaps slow the effects of aging, according to a
University of California, Berkeley, biochemist.

-Brain Center Searches for Patterns
Duke University Medical Center researchers have discovered the brain region
that automatically watches for patterns in sequences of events, even when
the pattern emerges by random happenstance.

-FEATURE: Antivirals, Anti-Cancers, and Antibiotics in One Pot
Panning parts of the chemical universe for compounds that are active against
particular biological targets has been an established route to drug
discovery since the early days of modern biology. Carbohydrate structures,
which surely have important biological activity given the volume of
carbohydrates in the body, have lagged behind the fields of protein and
nucleic acid recognition. Scripps Research Institute Investigator, Chi-Huey
Wong, suspects that times are changing.

-FEATURE: Small Wonders
"The small has become as limitless as the large," declared National Science
Foundation (NSF) Director Rita Colwell in her keynote kickoff to the NSF's
Small Wonders: Exploring the Vast Potential of Nanoscience conference held
in Washington, D.C. This very upbeat conference is in marked contrast to the
skepticism expressed only a decade ago about the prospects of engineering
devices at the scale of nanometers--one-billionth of a meter--just slightly
larger than many atoms.

-FEATURE: The Protein With A Topological Twist
It was in the 1960s that scientists first discovered the use of Oldenlandia 
affinis as a uteroactive agent that strengthens contractions and shortens 
delivery. O. affinis is a perennial weed with a woody root and blue-violet 
flowers, and is found in the tropical zones of Africa and western Asia. The 
main uteractive agent turned out to be a small protein named after the 
traditional medicine from which it was extracted: kalata B1.

To view Industry news, visit:

To view Research news, visit:


1)  “Structural Genomics: A New Field Unfolds”
Broadcast Friday, April 5, 2002

*Click here to listen to the audio recording:

*Click here to enter a drawing for a giveaway from Bio.com and our sponsor,
Roche Applied Science:

2)  “BioIT: Knowledge Management”
Broadcast Thursday, March 7, 2002

*Click here to view the PDF transcript:

*Click here to listen to the audio recording:

*For information on how to tune in to Bio.com’s live webcasts, go to:

*To view past InFocus Webcast recordings and transcripts, go to:



May 4th, 2002
10am – 3pm


Oakland Marriott Convention Center
550 10th Street
Oakland, CA 94607

Looking for a job?  Planning for the future?

Find the right job at the Bio.com Job Fair and network with top notch 
biotechnology and pharmaceutical representatives.  Employers in the
biopharmaceutical industry are out there looking for candidates with
your background.  The admission for job seekers is free.

For more information regarding the job fair, please visit:


Look at what’s new in the Bio.com Career Center this week:

1.  Serono:  Medical Liason

2.  Stowers Institute for Medical Research:  Senior Research Specialist 
in Genomics

3.  Pfizer Global Research & Development:  Research Associate/Sr. Research

4.  Millennium Pharmaceuticals:  Sr. Director, Science/Research

5.  Essential Therapeutics:  RA--Crystallography

6.  Corus Pharma:  Documentation Specialist

Click here to browse all jobs from Bio.com’s Career Center:


Bio.com offers the most comprehensive collection of market research.

-Structural Proteomics: High-Throughput Approaches Fuel Drug Discovery and
Structural proteomics--determining the three-dimensional structures of large
numbers of proteins--has emerged as one of the most immediately applicable
tools for drug discovery and development. The field has expanded rapidly and
now offers new tools and data to improve and accelerate the selection of
drug leads and to allow quick identification of the most valuable drug
targets from genomics.

-Antisense Therapeutics: The Emerging World Market
Antisense therapeutics are the buzz of the biotech sector, promising to
effectively treat many intractable diseases, including cancer, viral
infections, and autoimmune diseases. Antisense works by blocking the mRNA
transcripts used to produce disease-causing proteins.  But: is this
excitement premature?

-Agbiotech: Genetically Altered Traits in Crop/Food Products and Ingredients
The potential benefits derived from agricultural biotechnology are plentiful
and sometimes staggering. In addition to feeding an increasingly hungry
world, agbiotech products can add nutritional benefits, provide a new
alternative to pharmaceutical deliveries and become an important source of
renewable resources.


Bio.com offers a very comprehensive selection of Life Science related
software. Check out these latest additions:

-ChemSite Pro
Unsurpassed Graphics for the Crystallographer! Build any crystal molecule!
ChemSite Pro includes all of the features of ChemSite Standard plus adds a
fully interactive crystal builder. A must for any crystallographer!

-Genamics Expression
Expression is a revolutionary new application for DNA and protein sequence
analysis. Utilizing a novel interface, Expression makes complex
computational analyses of sequence information incredibly simple. Expression
uses the very latest computing technology to set new standards in the way
sequences are analyzed.

-Array Designer 2
DNA Microarray Software: Batch PCR primer design and hybridization
probe design tool for Windows.  Supports many specialized needs like ORF
studies and SNP detection using primer extension. Can be used with DNA chip
and gene chip arrays.

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