Life Sciences News Update / Bio Online newsletter at
Thu Jul 4 03:20:52 EST 2002 Life Sciences News Update
July 4, 2002

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Portal to the Life Sciences(tm) |

=========================================================================== Life Sciences News Update
July 4, 2002

Produced by Bio Online(r)
Portal to the Life Sciences(tm) |

=========================================================================== Life Sciences News Update
July 4, 2002

Produced by Bio Online(r)
Portal to the Life Sciences(tm) |



1.  Science News:  "Gene Therapy Technique to Switch Off Genes"
2.  InFocus:  "Pharmacogenomics: Applications in Drug Development"
3.  Career Center:  The "Next Generation" Career Center is here
4.  Jobs of the Week:  "Senior Engineer" and others
5.  Market Research:  "Proteomics 2002: Commercial & Technological Potentials"
6.  Featured Software:  "Array Designer 2" and others


-Gene Therapy Technique to Switch Off Genes

Genes that are inappropriately turned on play a critical role in triggering
some diseases. For researchers, the trick is learning how to deactivate
these genes to treat illnesses. In a step toward reaching that goal,
scientists at Stanford University Medical Center have developed a
gene-therapy technique to switch off genes in mice. The finding could
potentially lead to ways of treating such diseases as cancer, hepatitis C
and AIDS.

-Plant Gene Could Increase Crop Yield

Working with a decorative plant, the petunia, scientists at Cornell
University have identified a gene that restores pollen production to sterile
plants. The finding, reported the week of July 8 in Proceedings of the
National Academy of Sciences, points the way to probable locations of
similar restorer genes in approximately 150 other plant species with the
so-called cytoplasmic male-sterility (CMS) defect and could facilitate
crop-plant hybridization for increased yields.

-Muscle Stem Cells Show Promise in Muscular Dystrophy Model

Scientists have isolated special muscle-generating stem cells that can
improve muscle regeneration and deliver the missing protein dystrophin to
damaged muscles in a mouse muscular dystrophy (MD) model, according to a
study published in the Journal of Cell Biology supported in part by the
National Institute of Arthritis and Musculoskeletal and Skin Diseases

-Vaccine Delays Onset of Prion Disease in Mice

Immunization with a non-toxic genetically engineered prion, a protein that
causes a group of fatal brain diseases, including mad cow disease, delayed
the onset of brain disease in mice, according to a preliminary study by NYU
School of Medicine researchers and colleagues.

-Sleep Improves Motor Skill Learning

Harvard Medical School researchers have confirmed the adage that practice
does, indeed, make perfect - but only if you also get a good night's sleep.
The study, released in the July 3 edition of Neuron, involved teaching
people to type a sequence of keys on a computer keyboard as quickly and
accurately as possible. The research showed the amount of improved
performance was directly correlated with the amount of Stage 2 (a stage of
non-rapid eye movement or NREM) sleep an individual was able to receive,
particularly late in the night.

-Improved X-Ray Machines Using Carbon Nanotubes

The basic technology that produces X-rays has remained essentially the same
for a century, but now scientists and physicians at the University of North
Carolina at Chapel Hill and Applied Nanotechnologies Inc. say they should be
able to improve it significantly. Experiments the team conducted have shown
they can cause carbon nanotubes, a new form of carbon discovered about a
decade ago, to generate intense electron beams that bombard a metal "target"
to produce X-rays.

-Gene Linked to Type 1 Diabetes

A newly discovered gene plays a dramatic role in diabetes among rats, and is
also present in nearly identical form in humans, according to researchers at
the University of Washington and their colleagues. Further study of the gene
may shed light on little-understood processes of the thymus, a vital part of
the body's immune system, which sometimes attacks insulin-producing cells in
the pancreas leading to type 1 diabetes.

-Clues to the Evolution of Photosynthesis

When early microbes evolved, some species developed ways to convert sunlight
into cellular energy and to use that energy to capture carbon from the
atmosphere. The origin of this process, known as photosynthesis, was crucial
to the later evolution of plants. The publication today of the analysis of
the complete genome sequence of an unusual photosynthetic microbe provides
important insights into studies of how that light harvesting mechanism
evolved and how it works today.

To view Industry news, visit:

To view Research news, visit:


1.  Our next InFocus webcast, "Pharmacogenomics: Applications in Drug
Development," is scheduled for Wednesday, July 10th at 10am Pacific Time.

For more information, visit:

2)  "Drug Discovery: Getting Virtual, Getting Real"
Broadcast Friday, June 7, 2002

*Click here to view the PDF transcript:

*Click here to listen to the audio recording:

*Click here to enter a drawing for a giveaway from our sponsors:

*To view all past InFocus Webcast recordings and transcripts, go to:


Did you know that over 73% of recruiters across the U.S. use the Internet
everyday to look for candidates?

Employers and recruiters in biotechnology depend on's Career
Center to provide them with access to talented life sciences professionals
like you!

Create a Job Seeker Profile today and get noticed by the top
employers in the life sciences industry.'s Career Center offers powerful tools to help you manage your

-Access thousands of job postings on

-Create your online resume and cover letter and apply for jobs

-Archive your resume so employers and recruiters can access it or store
it privately for your own use

-Create up to 5 automatic job search agents that email you when your
criteria match a job opening


Look at what's new in the Career Center this week:
1.  Agensys, Research Associate

2.  Corus Pharma:  Director, Regulatory Affairs

3.  Clinimetrics:  Clinical Program Manager

4.  Immusol:  Bioinformatics Director

5.  CV Therapeutics:  Associate/Senior Associate, Quality Assurance

6.  Corestaff Services:  Senior Engineer

7.  Women First HealthCare:  Sales Analyst

Register today and start using our new features:

Click here to browse all jobs from's Career Center:

=========================================================================== offers the most comprehensive collection of market research.

-Ghrelin: The Future of Obesity Therapeutics?

The world obesity market has been predicted to reach $3.7 billion by 2008
with a compound annual growth rate of 21.1%. This market potential has caused
pharmaceutical companies to prioritize the identification of novel
anti-obesity products and Ghrelin represents one of the most promising
breaking targets in the field of obesity. LeadDiscovery, in collaboration
with one of the global leaders in ghrelin research has produced a state of
the art dossier describing why and how ghrelin should be targeted and how
ghrelin sits in the context of existing therapies and candidates in
development for the treatment of obesity. In short this dossier offers a
"one stop shop" for personnel involved in the selection, development and
commercialization of novel obesity projects.

-Proteomics 2002: Commercial & Technological Potentials

What is proteomics? What is all the excitement about? Why all this sudden
attention at conferences, in reports, in the media? Is it just a new
buzzword? How does it relate to genomics? How will it impact drug discovery?
Will it help people make money? If so, who and how? There are a lot of
questions about proteomics, as well as a fair amount of confusion. This is
to be expected with a new area of science that has burst upon the scene so
quickly. This report is designed to help answer these questions and to
provide readers with a roadmap through this complex and multifaceted area.

-Btech Weekly- July 1, 2002: New Trials for Insomnia, Diabetes, and Crohn

Btech Weekly is an overview of the current week's events in the
biotechnology and pharmaceutical industries.  The biotech sector finally
moved a bit higher this week, perhaps because of a lack of bad news more
than an abundance of good news. Neurocrine, Isis, and Amylin began important
phase II and III trials. A study presented at the European Neurological
Society in Berlin supported expanded use of Biogen's Avonex.

Click here to browse through our publications catalogue:

=========================================================================== offers a very comprehensive selection of Life Science related
software. Check out these latest additions:

-Fusion Pro

D.o.E. FUSION is a fully integrated, full 32-bit enabled stand-alone
software package. It's advanced capabilities far exceed those available in
any software package featuring Design of Experiments (D.o.E.) methods.
D.o.E. FUSION combines advanced Data Mining Technology with state-of-the-art
Design of Experiments capabilities in an extremely simple to operate
graphical interface.

-Array Designer 2

DNA Microarray Software: Batch PCR primer design and hybridization probe
design tool for Windows.  Supports many specialized needs like ORF studies
and SNP detection using primer extension. Can be used with DNA chip and gene
chip arrays.

-CESAR - Capillary Electrophoresis Simulation for Applications in Research

CESAR is a computer software for the simulation and optimization of
capillary electrophoresis applications. The program simulates the separation
based on a few specific properties such as pK, molecular weight and
mobility. Separation methods in the CE require a large number of parameters
which strongly influence the separation of the involved components. It takes
a lot of time and work to consider all those parameters in the separation
method. The simulation software CESAR enables the CE user to simulate
applications and separation methods at the PC without using the CE device
and thus receiving important clues about the planning of experiments.

Click here to browse through our software catalogue:

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