Life Sciences News Update

Bio.com / Bio Online newsletter at bio.com
Wed May 29 03:12:31 EST 2002

Bio.com Life Sciences News Update
May 29, 2002

Produced by Bio Online®
Portal to the Life Sciences(tm)
www.bio.com | www.bioprotocol.com



1.  Science News: “Studying Smallpox Without Smallpox”
2.  InFocus:  “Protein Kinases” — hear what the experts have to say
3.  Career Center:  The “Next Generation” Career Center is here
4.  Jobs of the Week:  “Senior Research Scientist” and others
5.  Featured Employer:  PPD
6.  Market Research:  “Therapeutic and Pharmaceutical Approaches to COPD”
7.  Featured Software:  “Buffer Maker” and others
8.  Featured Company:  BIOTECH Magazine

Newsletter Sponsored by:  IBC USA Conferences

IBC’s Drug Discovery Technology™ 2002: 
The World’s Drug Discovery Meeting Place
August 4-9, 2002 * The Hynes Convention Center * Boston, MA
Your opportunity to learn the latest in drug discovery and 
network with 5,000+ leaders in the field.  
For more information:

**To receive a 10% discount for the Drug Discovery Technology 2002
conference, click here:


-Gene Therapy Reverses Infertility In Male Mice
A team led by Salk Institute scientists has used gene therapy to reverse
infertility in male mice. Treated mice produced healthy offspring that did
not contain the introduced gene or vector, alleviating concerns that
treating infertility via gene therapy would genetically alter any progeny
produced from the treatment, as well as their descendants in perpetuity.

-Evidence That New Species Form Gradually
A study of birds on Pacific islands shows conclusively that the formation of
new species is a gradual and not a sudden process, according to biologists
from the UK, France, Australia and the USA writing in the May 28 issue of
Proceedings of the National Academy of Sciences.

-Depression Linked to Persistent Serotonin Abnormality
About 10 years ago, Dr. Robert Golden and University of North Carolina at
Chapel Hill colleagues discovered that depressed people showed a blunted
hormonal response to a test he developed that boosts serotonin, an important
neurotransmitter chemical in the brain. Now, newly published work by his
laboratory shows that as a group, people suffering from the illness have
that biological abnormality even when they are not depressed.

-Studying Smallpox Without Smallpox
Due to the nature of variola, the virus that causes smallpox, researchers
cannot access the virus conventionally. In this era of bioterrorism,
researchers at the University of Pennsylvania School of Medicine have
discovered a way to study how smallpox overcomes the human immune system.
Their results suggest new means to develop safer vaccines and potential
therapies for smallpox.

-Detecting Alzheimer's Decades Before Symptoms
MRI scans of the brain may detect Alzheimer’s disease decades before the
first clinical signs of dementia occur, researchers from the University of
South Florida (USF) and the University of Kentucky report in the journal

-FEATURE: Penicillin-Binding Proteins
Bacteria pose a continual threat of infection, both to humans and to other
higher organisms. Thus, when looking for new ways to fight infection, it is
often productive to look at how other plants, animals and fungi protect
themselves. This is how penicillin was discovered...

-FEATURE: Pump Up The Volume
The cochlea is a part of our inner ear that acts as a sound amplifier and
without it the noises which surround us would be mere fuzz. How does it
amplify sound? One theory is based on the behavior of a modest-sized
protein: prestin. Besides the fact that prestin is at the heart of sound
amplification theories, it also happens to be the only cellular motor to
date which does not need the help of biological energy, such as ATP, to

To view Industry news, visit:

To view Research news, visit:


1)  "Therapeutic Drug Targets: Protein Kinases"
Broadcast Friday, May 10, 2002

* Click here to view the PDF transcript:

*Click here to listen to the audio recording:

*Click here to enter a drawing for a giveaway from our sponsors:

*For information on how to tune in to Bio.com’s live webcasts, go to:

*To view all past InFocus Webcast recordings and transcripts, go to:


Bio.com announces the “Next Generation” Career Center!

-Over 1,800 biotechnology positions at your fingertips
-New features available making your job search more powerful than ever

Visit us today to set up your FREE personal profile:


Look at what’s new in the Bio.com Career Center this week:

1.  CellGate Inc.:  Scientist 

2.  UC Davis Genome Center:  BioInformatics Professor

3.  Real-Time Solution:  Senior Scientist

4.  Onyx:  Clinical/Preclinical Development Associate

5.  ZymoGenetics:  Scientist

6.  OSI Pharmaceuticals:  Medical Writer

7.  Vertex:  Associate Scientist-Peptides

8.  Millennium:  Program Director-Bayer program

9.  Aventis:  Senior Research Scientist

Register today and start using our new features:

Click here to browse all jobs from Bio.com’s Career Center:


PPD- Experience the world of drug discovery and development at PPD. As a
leading global provider of discovery and development services and products
for pharmaceutical and biotechnology companies, we’re in the business of
making a difference. Please view our careers page for current openings:


Bio.com offers the most comprehensive collection of market research.

-Therapeutic and Pharmaceutical Approaches to COPD
There is a pressing need to develop new treatments for chronic obstructive
pulmonary disease (COPD), as no currently available drug therapy reduces the
relentless progression of the diseases, chronic obstructive bronchitis and
emphysema, falling under the umbrella of COPD. World-wide, 600 million
people suffer from COPD, with some three million dying from the disease each
year representing a global market of $2.8 billion US. This major
dossier, cowritten by Professor Peter Barnes, head of Thoracic Medicine at
the National Heart and Lung Institute and one of the world's field leaders
in COPD, and Dr. Jon Goldhill, Chief Analyst at LeadDiscovery, offers a
major insight for all companies or research groups wishing to target the
unmet field of COPD.

-Ophthalmology Device & Diagnostic Markets Series
Volume 1: Ophthalmic Diagnostics: Worldwide and U.S. Markets, the first
volume in Theta Reports' Ophthalmology Device & Diagnostic Markets Series,
addresses how changing demographics will impact the world ophthalmics
market, the diagnostic technologies that are on the market and in
development, and who is developing them. Volume 2: Ophthalmic Surgery:
Worldwide & U.S. Markets covers how the changes in reimbursement regulations
and how the graying of America will affect this market. Volume 3: Contact
Lenses: Worldwide & U.S. Markets provides insight into the advancing
technologies that are driving growth in the contact lens market and who will
benefit from this growth.

-The Surging Microarray Biochip Business
While microarrays were invented during the 1980s, they have not come into
significant use until the last couple of years. One of the biggest drivers
of this market has been the completion of the Human Genome Project, probably
one of the most important projects in science. The goal of this market
research study is to determine the present market for microarray biochips,
arrayers, scanners, and microfluidics chips, and to predict the future
revenues worldwide for these products and the average annual percentage
growth rates. It also explains the current technologies in basic language,
examines developments in each market, and discusses the present and future
issues in the market.

Click here to browse through our publications catalogue:


Bio.com offers a very comprehensive selection of Life Science related
software. Check out these latest additions:

Quickly and easily draw molecules in a chemistry-oriented interface.
Instantly calculate the chemical formula, molecular weight, and percentage
composition. Predict several liquid properties such as density and
refractive index.  Customize display properties, e.g., atom numbering,
chemical symbols, and valence.  Draw reactions, schematic diagrams and
design other chemistry-related reports and presentations.  Work with
structures, text and graphics simultaneously and transfer to any
OLE-supported software.

-Buffer Maker
Buffer Maker assists you in designing your own buffers using the
Henderson-Hassellbalch equation. If you want to use a pre-designed buffer
you can choose a buffer from a library of over 500 buffer recipes! Buffer
Maker will also calculate % constituent, ionic strength, dilution values, or
standardization values. In addition, pH, pK and pKa calculations are easily
performed with Buffer Maker.

-Grapher 3.0
Grapher is an easy to understand technical graphing package for anyone who

Click here to browse through our software catalogue:


BIOTECH Magazine

BIOTECH is a full-colour magazine about the business and science of
biotechnology.  It is a visually stunning publication aimed at
executives and senior scientific personnel.  Examining breakthrough
developments in the science of biotechnology accompanied by
authoritative advice about funding issues, intellectual property
strategies, the regulatory environment, ethical challenges, and much
more, the magazine is a "must read" for all those interested in the
rapidly evolving life sciences. For more information:

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