number of alleles of a gene

Dr N.I.Leaves nleaves at hgmp.mrc.ac.uk
Wed Dec 19 06:33:31 EST 2001


I think this is uncontentious and quite common knowledge. Also it does in
a small way support my argument - the longer a bit of DNA the more
variable it will be. 

I have previously searched for microsatellite repeats and know from trial
and error that dinucleotide repeats are not worth testing for polymorphism
if they are <10 repeating units. There are so many CA repeats in the
genome why look at short ones which might be unproductive? the longer
ones are almost always variable.

nick

On 18 Dec 2001, Brown, Donna wrote:

> You may want to check out the following citation.  I believe they looked at
> SSR length in relation to polymorphism rate.
> 
> Am J Hum Genet  1989 Mar;44(3):388-96
> 
> Abundant class of human DNA polymorphisms which can be typed using the
> polymerase chain reaction.
> 
> Weber JL, May PE.
> 




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