server for identification of human repetitive DNA

A. Milosavljevic b44340 at ACHILLES.CTD.ANL.GOV
Thu Aug 20 13:58:53 EST 1992



Identification of Human Repetitive DNA Elements via Electronic Mail

                    Aleksandar Milosavljevic
            Biological and Medical Research Division
                   Argonne National Laboratory
                  Argonne, Illinois 60439-4833

                           Jerzy Jurka
         Linus Pauling Institute of Science and Medicine
                       440 Page Mill Road
                   Palo Alto California 94306

  An electronic mail server at pythia at anl.gov has been installed that
performs two kinds of tasks:

(1) Identifies occurrences of around 50 known repetitive elements in human
genomic DNA sequences.

    The regions that are identified as occurrences of repetitive elements
  in the incomming DNA sequence are aligned against the repetitive
  element. The alignments are then mailed back to the sender.

(2) Identifies subfamily membership of Alu sequences

    The incoming sequence is first aligned against the Alu consensus
  sequence and then it is identified as belonging to one of the
  subfamilies of Alu sequences based on the bases in a set of diagnostic
  positions.

  To obtain more detailed information on the current availability of
the services and on examples of its use, send a message with a word
"help" in the "Subject"-line to the internet address pythia at anl.gov.

  The server is still in the testing phase, so please report any
problems.  We would also appreciate your comments on possible
improvements of the server. Send your comments to pythia-admin at anl.gov.

  Work supported by the Grant DE-F603-91ER61152 from the U. S.
Department of Energy, Human Genome Program, and in part by the U.S.
Department of Energy, Office of Health and Environmental Research,
under Contract No. W-31-109-ENG-38.

  The U. S. Government retains a nonexclusive, royalty-free license to
publish or reproduce the published form of this contribution, or allow
others to do so, for U. S. Government purposes.






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