biotechnology educational software

Matthias Wjst WJST at GSF.DE
Fri Aug 20 02:58:00 EST 1993


In Article <oxford.745802469 at cmgm.stanford.edu> "oxford at cmgm.stanford.edu (Oxford Molecular Ltd.)" says:
> I teach a course at U.C. Berkeley extension each fall titled "Molecular Genetics".  The course has expanded to cover much of modern molecular biology and biotechnology in general, which I am finding increasingly hard to cover with any
> single textbook.
> 
> I would be interested in hearing from anyone who has seen or developed any
> interactive software for demonstrating concepts and principles of any aspect 
> of modern molecular biology.  I would also be interested in getting feedback
> from people on their opinions of such packages, and any views they might
> have for developing novel interactive educational software in this field.
> 
> Any help that I can get would be most welcome. My students are tired of
> reading outdated texts and research papers are generally too dense. Please E-mail to me alone (oxford at cmgm.stanford.edu), I will summarize for the Net if
> there is enough interest.
> 
> Thanks in advance,
> 
> Sincerely,
> -Sunil Maulik
> oxford at cmgm.stanford.edu
> (415) 494-6274
> 
Last weeek i have received a very nice software for MS-DOS PC,
from where the contents page will follow.
Hope this will help you,
Matthias Wjst
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    This message came from Munich: WJST at GSF.DE
    Dr. Matthias Wjst, Institut fuer Epidemiologie     
    GSF Forschungszentrum fuer Umwelt und Gesundheit   
    Neuherberg, Ingoldstaedter Landstr.1, P.O.B. 1129  
    85758 Oberschleissheim, Germany
    Phone +49-89-3187/ -4565, Fax  /-3380
    i am epidemiologist no. 3:^:3:3[3:]3:]33
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                           Documentation for GREGOR:
                        Software for Genetic Simulation
                                 Release 1.3.4
                            Thursday July 22, 1993
                       Please address correspondence to:
                                    GREGOR
                             c/o Dr. Diane Mather
                          Department of Plant Science
                      McGill University, Macdonald Campus
                    21,111 Lakeshore, Ste-Anne-de-Bellevue
                            Qubec, Canada, H9X 3V9
                               FAX: 514-398-7897
                         EMail: indm at musicb.mcgill.ca
                                    CONTENTS
                                                                          page
Chapter 1. . . . . . . . . . . . INSTALLATION. . . . . . . . . . . . . . .   4
      DISTRIBUTION FILES . . . . . . . . . . . . . . . . . . . . . . . . .   4
      INSTALLING GREGOR. . . . . . . . . . . . . . . . . . . . . . . . . .   4
Chapter 2. . . . . . . . . . INSTRUCTIONS FOR USE. . . . . . . . . . . . .   4
      STARTING GREGOR. . . . . . . . . . . . . . . . . . . . . . . . . . .   4
      CHOOSING OPTIONS . . . . . . . . . . . . . . . . . . . . . . . . . .   4
      WHERE TO GO NEXT . . . . . . . . . . . . . . . . . . . . . . . . . .   5
Chapter 3. . . . . . . . . . .SIMULATION CONCEPTS. . . . . . . . . . . . .   6
      THE GENOME . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   6
      DEFINING INPUTS. . . . . . . . . . . . . . . . . . . . . . . . . . .   6
      GENETIC MANIPULATIONS. . . . . . . . . . . . . . . . . . . . . . . .   6
      EVALUATION OF RESULTS. . . . . . . . . . . . . . . . . . . . . . . .   7
Chapter 4. . . . . . . . . . . A SAMPLE TUTORIAL . . . . . . . . . . . . .   8
      GETTING STARTED. . . . . . . . . . . . . . . . . . . . . . . . . . .   8
      DEFINING POPULATIONS . . . . . . . . . . . . . . . . . . . . . . . .   8
      VIEWING GRAPHICAL GENOTYPES. . . . . . . . . . . . . . . . . . . . .   9
      MAKING CROSSES . . . . . . . . . . . . . . . . . . . . . . . . . . .   9
      GENETIC MARKERS. . . . . . . . . . . . . . . . . . . . . . . . . . .  10
      QUANTITATIVE TRAITS. . . . . . . . . . . . . . . . . . . . . . . . .  11
Chapter 5. . . . . . . . . . . REFERENCE MANUAL. . . . . . . . . . . . . .  13
      THE MAIN SCREEN. . . . . . . . . . . . . . . . . . . . . . . . . . .  13
      STATUS LINE. . . . . . . . . . . . . . . . . . . . . . . . . . . . .  13
      GENOME DEFINITION. . . . . . . . . . . . . . . . . . . . . . . . . .  13
      MEMORY AVAILABLE . . . . . . . . . . . . . . . . . . . . . . . . . .  13
      POPULATION WINDOW. . . . . . . . . . . . . . . . . . . . . . . . . .  13
      TRAIT WINDOW . . . . . . . . . . . . . . . . . . . . . . . . . . . .  13
      MARKER WINDOW. . . . . . . . . . . . . . . . . . . . . . . . . . . .  13
      TEXT WINDOW. . . . . . . . . . . . . . . . . . . . . . . . . . . . .  13
      MAIN MENU. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  14
      MENU HIERARCHY . . . . . . . . . . . . . . . . . . . . . . . . . . .  14
      POPULATION MENU. . . . . . . . . . . . . . . . . . . . . . . . . . .  14
      DEFINE POPULATION. . . . . . . . . . . . . . . . . . . . . . . . . .  14
      SAVE POPULATION. . . . . . . . . . . . . . . . . . . . . . . . . . .  15
      RETRIEVE POPULATION. . . . . . . . . . . . . . . . . . . . . . . . .  15
      DELETE POPULATION. . . . . . . . . . . . . . . . . . . . . . . . . .  15
      SUMMARIZE POPULATION . . . . . . . . . . . . . . . . . . . . . . . .  15
      GRAPHICAL GENOTYPES. . . . . . . . . . . . . . . . . . . . . . . . .  15
      MANIPULATION MENU. . . . . . . . . . . . . . . . . . . . . . . . . .  15
      DOUBLED HAPLOIDS . . . . . . . . . . . . . . . . . . . . . . . . . .  15
      SELFED PROGENY . . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      CLONAL PROGENY . . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      SINGLE SEED DESCENT. . . . . . . . . . . . . . . . . . . . . . . . .  16
      RECOMBINANT INBREDS. . . . . . . . . . . . . . . . . . . . . . . . .  16
      MERGE POPULATIONS. . . . . . . . . . . . . . . . . . . . . . . . . .  16
      CROSSING MENU. . . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      SPECIFIC HYBRIDS . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      RANDOM MATING. . . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      CHAIN CROSSES. . . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      FULL DIALLEL . . . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      DESIGN II. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      BACKCROSSES. . . . . . . . . . . . . . . . . . . . . . . . . . . . .  16
      TRAIT MENU . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  17
      DEFINE A TRAIT . . . . . . . . . . . . . . . . . . . . . . . . . . .  17
      CHANGE A TRAIT . . . . . . . . . . . . . . . . . . . . . . . . . . .  18
      SAVE A TRAIT . . . . . . . . . . . . . . . . . . . . . . . . . . . .  18
      RETRIEVE A TRAIT . . . . . . . . . . . . . . . . . . . . . . . . . .  18
      VIEW A TRAIT . . . . . . . . . . . . . . . . . . . . . . . . . . . .  18
      DELETE A TRAIT . . . . . . . . . . . . . . . . . . . . . . . . . . .  18
      MARKER MENU. . . . . . . . . . . . . . . . . . . . . . . . . . . . .  18
      DEFINE MARKER LIST . . . . . . . . . . . . . . . . . . . . . . . . .  18
      SAVE MARKER LIST . . . . . . . . . . . . . . . . . . . . . . . . . .  19
      RETRIEVE MARKER LIST . . . . . . . . . . . . . . . . . . . . . . . .  19
      VIEW MARKER LIST . . . . . . . . . . . . . . . . . . . . . . . . . .  19
      DELETE MARKER LIST . . . . . . . . . . . . . . . . . . . . . . . . .  19
      EVALUATION MENU. . . . . . . . . . . . . . . . . . . . . . . . . . .  19
      TRAIT PHENOTYPES . . . . . . . . . . . . . . . . . . . . . . . . . .  19
      TRAIT SUMMARY. . . . . . . . . . . . . . . . . . . . . . . . . . . .  19
      MARKER PHENOTYPES. . . . . . . . . . . . . . . . . . . . . . . . . .  19
      MARKER SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . .  20
      TRAIT + MARKERS. . . . . . . . . . . . . . . . . . . . . . . . . . .  20
      MAPMAKER FILE. . . . . . . . . . . . . . . . . . . . . . . . . . . .  20
      DRAW A HISTOGRAM . . . . . . . . . . . . . . . . . . . . . . 



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