Database Search

Enrique Vargas Madrazo evargas at UV4.INVEST.UV.MX
Tue Jun 21 20:07:41 EST 1994


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Dear colleagues:

	We have been working on the obtaining of Ig sequences; our
interest is the building of an immunoglobulin gene sequence database.
	There is impossible to access extensively any specific
database (Germline genes, Pseudogenes, Rearranged genes, etc.) using a
server. This is because there are not consistent rules in the assigned 
keywords to sequences of the same type. For example, there are not one 
keyword that can be found in all the pseudogenes of the Ig heavy variable 
domain in GenBank (either in definition or keyword fields).
	In many other databases like PIR and Kabat, the problems are similar.
That is, THERE ARE MANY INCONSISTENCES IN THE CODIFICATION PROCEDURES OF THE 
INFORMATION THAT SPECIFIES THE CHARACTERISTICS OF THE SEQUENCES.
	We think that in the context of the tremendous growth rate of the 
databases, this deficiency constitutes a very hard problem for the
management, organization and rational analysis of the sequences.
 	It is important to catch the eye of the database manager about this 
problematic situation.

******************************************************************************
*                                *         evargas at uv4.invest.uv.mx          *
*    Dr. Enrique Vargas-Madrazo  *       evargas at speedy.coacade.uv.mx        *
*                                *  optional: salazar at redvax1.dgsca.unam.mx  *
******************************************************************************
* Laboratorio de Biologia Molecular      *  Phone number: (28)125757         *
* e Inmunologia Teorica.                 *  FAX number: (28)125757           *
******************************************************************************
* Instituto de Investigaciones Biologicas *   Universidad Veracruzana        *
*                                         *   Xalapa, Veracruz; Mexico.      *
******************************************************************************
                    *           POSTAL ADRESS:           *
                    *       Juan de la Barrera 54,       *
                    *  Col. Electricistas,  C.P. 91000   *
                    *      Xalapa, Veracruz; Mexico      *
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