Program for testing constancy of evolutionary rates available

Joaquin Dopazo dopazo at samba.cnb.uam.es
Fri Apr 21 09:53:26 EST 1995


A nalysis  of            Version 1.0       (c) J. Dopazo, 1994, 1995
 B ranch                 Centro Nacional de Biotecnologia
  L ength	         Universidad Autonoma, 28049, Madrid, SPAIN
   E rrors			


DESCRIPTION

  This is a package of three programs which allows you to perform the test for 
constancy in the evolutionary rates by Adell and Dopazo (1994) based on branch 
lengths. The programs have been developed to be used together with the PHYLIP 
(Felsentein, 1993) package (indeed, at least FITCH and KITSCH programs are 
necessary). The aim was to make accessible, in an easy way, this test within the 
framework provided by the PHYLIP package.

THE TEST

  The idea of the test is to simulate a large number of evolutionary processes 
corresponding to the proposed model and then to construct the statistical distribution 
of the desired parameters, in this case the branch lengths. After, a tree is reconstructed 
without the constraints imposed by the model and it can be checked whether the 
observed branch length values fall within the expectations of the model or not. The test 
is described in detail in:

Adell, J.C. and Dopazo, J. (1994) Monte Carlo simulations in phylogenies: an 
application to test the constancy of evolutionary rates. J. Mol. Evol. 38:305-309.

AVAILABILITY

ABLE is available in internet:
At the URL:             HTTP://WWW.CNB.UAM.ES/WWW/XIMO/WWW1.HTML 
or by anonymous FTP at: FTP.CNB.UAM.ES/SOFTWARE/MOLEVOL/ABLE-DOS.EXE

Or sending a diskette 3 1/2" to the address:
		
J. Dopazo
Centro Nacional de Biotecnologia, CSIC.
Universidad Autonoma. 28049 Cantoblanco, Madrid.
SPAIN


Questions and comments on ABLE can be sent to 
DOPAZO at SAMBA.CNB.UAM.ES


=======================================================
J. Dopazo.   Centro Nacional de Biotecnologia - CSIC
             Universidad Autonoma, 28049 Madrid, SPAIN
             tf.  34 1 5854513
             fax  34 1 5854506

DOPAZO at SAMBA.CNB.UAM.ES
=======================================================




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