3D-proteine structure: Homology modeling versus X-ray chrystallography

[C. Rebeiz]

One of the major limitations of homology modeling in plants systems, is
finding a reference protein with
a degree  of homology = or > than 40% to the target protein.  I wonder
however, about the relationship of a laboratory-grown crystal of a
membrane-bound solubilized protein to the native protein in situ. 
Constantin A. Rebeiz
240 A, PABL
1201 W. Gregory
Univ. Illinois, Urbana, IL 61801