For manual alignments I invite you to try my multiple sequence editor Esee3 which is available via anonymous ftp from: trog.mbb.sfu.ca (directory pub/esee) or alanine.gcg.com (directory pub/msdos) the files of interest are: esee3zip.exe and xeseezip.exe Eric Cabot cabot at gcg.com -- Regards, Eric L. Cabot cabot at gcg.com