Ross D. King rd_king at icrf.icnet.uk
Mon Sep 30 11:42:26 EST 1996

DSC Protein Secondary Structure Prediction

I am pleased to announce the opening of a new web site for 
the prediction of protein secondary structure.
Two prediction modes are available:

1) Given a single sequence.  A multiple sequence alignmentt 
will be formed and DSC used to predict secondary structure.

2) Given a  multiple sequence alignmnet.  DSC will 
use this alignment to predict secondary structure.

The advantages of DSC are:
1) It is very accurate.  DSC has a prediction accuracy of 70.1% on a 
standard set of 126 proteins.  This was not significantly different 
from PHD, a popular prediction method.  For medium length sequences 
DSC was more accurate than PHD, and combining DSC and PHD produced 
a prediction method more accurate than either.

2) It is free.  There is no charge for using DSC.  

3) The C source code is available.  This would allow you 
to run DSC on your own system if you had confidential sequences.

DSC is based on simple linear statistics.  A paper on the
scientific basis of DSC will appear in Protein Science:
"Identification and Application of the Concepts Important for
Accurate and Reliable Protein Secondary Structure Prediction"
by Ross D. King & Michael J.E. Sternberg

Ross D. King
Biomolecular Modelling Laboratory
Imperial Cancer Research Fund
Lincoln's Inn Fields, P. O. Box 123,
London, WC2A 3PX, U.K.
Tel: +44 171 269 3565, Fax: +44 171 269 3479,
rd_king at icrf.icnet.uk
m.sternberg at icrf.icnet.uk (contact until 25 Oct 96)


*         from e-mail address:   m.sternberg at icrf.icnet.uk             *
*                                                                      *
* Mike Sternberg                      Tel +44-71-269-3565 / 3591       *  
* Biomolecular Modelling Laboratory   FAX +44-71-269-3479              *
* Imperial Cancer Research Fund       Others in group who can help :   *
* 44 Lincoln's Inn Fields             Suhail Islam Tel +44-71-269-3380 *
* London WC2A 3PX, England            Paul Bates   Tel +44-71-269-3348 *

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