Question: Determination of Tm of non-perfect fitting DNA-duplexes?

Ming-Piao Kao mingpiao at
Wed Jan 22 08:31:49 EST 1997

Does anyone know how one can determine the melting-temperature of 2 DNA-
strands which have several mismatches between them ?? And is this
possible using GCG software(to which I have access) ?

Thank you very much for any help,

De'de' Kao
mingpiao at

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