Preader & curvefitting, Interactive Explorer for Preader, and Pbase a standalone application

Lars Thomsen lthomsen at
Mon Jul 14 04:19:39 EST 1997

Preader is freeware and used to measure, analyze and store and cross
analyze data from physiological experiments - mainly wholecell
but the database part is independent and includes a wealth of utilities
which is extremely useful for any phys or molbiol lab.

We are working on an advanced non-linear curvefitting model that will
improve the kinetic information that can be obtained from a whole cell
current. The algorithm will search through the whole cell current and
break it into pieces and then extract the rate constants descriping
kinetic scheme :

Closed <---> Open <---> Desensitized

The Interactive Explorer is a high tech help file that gives you the
settings of your program and explains them. It also includes various
help features which includes theory for common physiological terms,
molecular biology, constants, equations, cells + much more

Preader have been broken up and the newest branch is called Pbase and it

covers the database part and it includes following tables :
Chemicals : Name,Formula,MW,Solvent,Solubility,PKa(if acid or base),
+ more

Solutions : Recipe database that creates excellent recipies and
Automatic lookup in chemical database

Agonist/Antagonist : Name, effect, chemicalstructure (path to picture),
interactionchart (path to picture), ChemIndex (lookup ID to chemical
database), References (list of references), EC50, IC50, Ka, Occupancy,
pD2,pA2, Kb, pKb, shieldSlope

Other tables included :
Phys data
PCR setup
RT setup
Taq setup
PCR data
Reference Groups

Preader homepage :
(this web page is outdated but send me a mail and Ill keep you updated
about the newest developments and download information)

Best Regards
Lars Thomsen MSc. PhD.
McMaster University
thomsenl at
or direct to the cottage
lthomsen at

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