BLAST versus BLAT, limit for the length of the query
karplus at bray.cse.ucsc.edu
Wed Jun 19 03:36:54 EST 2002
>> 2. Has anyone here experience with the new "Blast" called Blat?
>> Do you think it will be faster than BLAST?
>> Are the results comparable?
BLAT is much faster than BLAST when doing many DNA-based searches in a
big genome like the human genome, but it will probably miss more
remote similarities than BLAST, as it has been mainly tuned for
mouse-human genomic distances. There are parameters that can be
adjusted to make it more sensitive but slower.
BLAT indexes the genome, which is fairly expensive, so is only a win
if you plan to do many searches.
Kevin Karplus karplus at soe.ucsc.edu http://www.soe.ucsc.edu/~karplus
Professor of Computer Engineering, University of California, Santa Cruz
Undergraduate Director, Bioinformatics
Affiliations for identification only.
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