MBx on the World Wide Web

M. Kelly mkelly at hgmp.mrc.ac.uk
Mon Feb 6 19:22:51 EST 1995


MBx on the World Wide Web

The European Collaborative Interspecific Backcross (EUCIB) provides
the resources for the high resolution genetic  mapping of the 
mouse genome. One of the primary aims is to construct a high resolution 
microsatellite map of all available simple sequence length polymorphisms 
across the entire mouse genome. The MBx database supports the mapping
effort. The database was constructed using distributed client/server
database - Sybase, Sybase application development tools (APT), the C and 
XView programming languages. MBx stores all locus, probe and SSLP data. 
Allele data at each locus is presented as a scrollable matrix on screen. 
MBx can compute genetic linkage between loci and in addition, can 
automatically perform the necessary haplotype analysis by minimising the
number of observed recombinants across any chromosome region in order
to derive genetic order of loci. Furthermore MBx can abstract all mice 
carrying recombinants in any chromosome region. Such information when 
downloaded to  robots is imported for the automated and error free selection
of correct DNA's for subsequent high resolution microsatellite mapping in a 
particular chromosome region.

To date the latest  EUCIB maps and mapping data, including ACeDB type 
Multimaps have been available via the UK HGMP Resource Centre Computing Menu.

MBx is accessed from the HGMP menu by typing 'mbx' at the menu prompt.
EUCIB genetic maps in "Encylopedia of the Mouse Genetic Map" format, and 
MBx-ACeDB Multimaps which compare MBx and MIT genetic data are available.

In addition MBx is now available on the World Wide Web.

http://www.hgmp.mrc.ac.uk/local-data/mbx/Mbx_Homepage.html

The following items are available via World Wide Web:
 -pedigree information from the EUCIB backcross,
 -probe and locus information,
 -haplotype panels,
 -genetic maps EotM format,
 -information on accessing the EUCIB User Service.



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