[DE] PROCRUSTES: New Gene Recognition Software

ppevzner at hto-d.usc.eduPavelPevzner ppevzner at hto-d.usc.eduPavelPevzner
Thu Nov 28 11:11:02 EST 1996


Announcement: New version of Procrustes gene recognition software now
available.
 
Version 3.01 beta of Procrustes is available as a WWW server:
 
          http://www-hto.usc.edu/software/procrustes/
 
or as an MS Windows application for the IBM PC.  Procrustes uses
previously-sequenced genes to recognize new ones as described in 

          Gelfand, M.S., Mironov, A.A.,Pevzner, P.A. 
          "Gene recognition via spliced sequence alignment", 
          Proc. Natl. Acad. Sci. USA (1996), 93, 9061-9066

The distinctive features of Procrustes are:
- high reliability of predictions (up to 99%) in the presence of related
  proteins as compared to 70-80% for most gene recognition programs;
- the possibility to analyze extremely long (up to 150,000 bp) sequences
  with many (up to 20-30) exons;
- insensitivity to statistical inhomogeneity of genomes;
- the possibility to recognize very short exons;
- insensitivity to the presence of several genes in one sequence.
 
Version 3.01 beta of the WWW server includes:
- graphical output for exon-intron maps and alignment profiles;
- gene recognition by spliced alignment to several related proteins.
 
The next release will include:
- gene recognition in various species;
- error-tolerant gene recognition;
- assignment of confidence levels to recognition results;
- using EST sequences for gene recognition;
- gene recognition in incomplete sequences.



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