protein interaction mapping

[jpaige1989 at netscape.net]

I'm a research student studying protein-protein interaction mapping,
seeing how the orthologous proteins in the already mapped datasets of
the worm, fruit fly, and yeast are being used to produce a putative
human protein interaction map. I wanted to know if anyone has
information on how protein maps are made in general and whether the
yeast two hybrid method or others are more accurate/beneficial.