dadler at u.washington.edu
Tue Dec 6 23:31:07 EST 1994
> hirshaut at yu1.yu.edu wrote:
> : ...What, however, is known about chromosome organization?
> : It would seem logical that genes with related functions share
> : a single chromosome. Is there, in fact, any information
> : so far that confirms this assumption?...
and, In article <3c0p82$58r at decaxp.harvard.edu> robison at lipid.harvard.edu
(Keith Robison) writes:
> However, the trend seems to be that genes with related function are only
> clustered if they are directly related by duplication. For example,
> the HOX genes occur in nice little clusters whose structure is largely
> conserved between flies and man. But the HOX genes are all related to
> each other by duplication.
But even more interesting, I think, and not explained by the duplication
origin of the homeotic clusters, is the situation of the fly Ant/bithorax
cluster and its mouse homolog. Within these clusters the order of the
individual genes on the chromosome (map) is paralleled by the order of
expression, anterior-posterior, of these genes in the embryo. And, this
parallel relationship between ordered chromosomal arrangement and spatial
expression pattern is conserved from fly to mouse!
David A. Adler Pathology SM-30
University of Washington Seattle, WA 98195
(206) 543-0716 (phone) (206) 543-3644 (fax)
"Science is nothing but trained and organized common sense"
More information about the Biochrom