* transloc chrom help please

faraco at cmgm.stanford.edu faraco at cmgm.stanford.edu
Mon Jun 10 20:32:36 EST 1996


HK wrote:
> 
> In <4pbtu5$sfc at newsbf02.news.aol.com> kabass at aol.com (KABass) writes:
> >
> >I am writing on behalf of a frightened, pregnant friend of mine who's
> >fetus has a balanced translocated chromosome (breaks at 7 Q34 and 13
> Q12).
> > Her genetic counselor has not been much help.  Neither parent shows
> the
> >trait.
> >
> >She's found recorded evidence of abnormality with translocations at 7
> Q32
> >and & 7 Q36.  She's been told that even if a translocation identical
> to
> >hers had been found in a past study, the researcher would only have
> >published results if an abnormality had resulted.
> >
> >How do we find someone with the same translocation to determine what
> the
> >effect may be on the child?  She's in NYC so has access to some good
> >doctors, but she's hoping someone from the 'net community may be able
> to
> >offer some innovative ideas for how to approach this dilemma.
> >
> >Much thanks--
> >Tim Walter
> >timothy at aspeninst.org or kabass at aol.com
> >202-736-5834 (day)
> =====================================================
> If it's balanced, as they say it is, it shouldn't have any effect at
> all.  The potential for problems would be in any child the affected
> individual may have (which can also be detected ahead of time by
> amnio).
> 
> HK


I strongly disagree with the above, and think this was an irresponsible
post. This isn't theory on a first year exam. This is a question of
potential life or death of a real fetus. The real problem is that
nobody can say whether this child will be normal. There isn't a simple
way of determining whether, or how much DNA was lost during the
translocation process.



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