Science/NCBI Human Transcript Maps

David Benton benton at EXTRA.NCHGR.NIH.GOV
Fri Oct 25 10:49:41 EST 1996

With thanks to Andy Baxevanis of NCHGR who wrote the original version
of this posting.  Note: neither Andy nor I are authors of the paper
described below, so perhaps it is not our place to call it to your
attention.  But, perhaps the authors are too busy or modest to do so...


An online version of Science's "The Human Transcript Map" wall chart
was made available yesterday on NCBI's Web site. The URL for the site

In addition to information and graphics from the wall chart, there are
details on "featured genes", a glossary of terms, and search engines
for browsing OMIM and the definition lines of GenBank records
corresponding to genes mapped in this study. Also, maps can be searched
to get a list of all cDNAs corresponding to a specific region of the
genome. Full text of the accompanying article (October 25 issue; Greg
Schuler, Mark Boguski, et al.) is also available; the abstract follows.


The human genome is thought to harbor 50,000 to 100,000 genes, of which
about half have been sampled to date in the form of expressed sequence
tags. An international consortium was organized to develop and map
gene-based sequence tagged site markers on a set of two radiation
hybrid panels and a yeast artificial chromosome library. More than
16,000 human genes have been mapped relative to a framework map that
contains about 1000 polymorphic genetic markers. The gene map unifies
the existing genetic and physical maps with the nucleotide and protein
sequence databases in a fashion that should speed the discovery of
genes underlying inherited human disease. The integrated resource is
available through a site on the World Wide Web at

[Science, Volume 274, Issue of 25 October 1996, pp. 540-546]

-David Benton, NCHGR

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