Human Chromosome 19 and Related Regions in Mouse: Conservative and Lineage-Specific Evolution

Rcjohnsen rcjohnsen at aol.com
Sun Jul 8 13:58:23 EST 2001


Genetics  

Human Chromosome 19 and Related Regions in Mouse: Conservative and
Lineage-Specific Evolution 

Paramvir Dehal,124 Paul Predki,15 Anne S. Olsen,12 Art Kobayashi,12 Peg
Folta,12 Susan Lucas,12 Miriam Land,18 Astrid Terry,12 Carol L. Ecale Zhou,12
Sam Rash,12 Qing Zhang,15 Laurie Gordon,12 Joomyeong Kim,12 Christopher
Elkin,13 Martin J. Pollard,16 Paul Richardson,15 Dan Rokhsar,17 Ed
Uberbacher,18 Trevor Hawkins,15 Elbert Branscomb,12 Lisa Stubbs12*  
To illuminate the function and evolutionary history of both genomes, we
sequenced mouse DNA related to human chromosome 19. Comparative sequence
alignments yielded confirmatory evidence for hypothetical genes and identified
exons, regulatory elements, and candidate genes that were missed by other
predictive methods. Chromosome-wide comparisons revealed a difference between
single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes
residing in tandem familial clusters, which differ extensively in number,
coding capacity, and organization between the two species. Finally, we
sequenced breakpoints of all 15 evolutionary rearrangements, providing a view
of the forces that drive chromosome evolution in mammals. 
Article available in PDF and found in Science  293




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