Neuropsychology of Schizophrenia: BBS Call for Commentators

S. R. Harnad harnad at phoenix.Princeton.EDU
Sun Apr 22 19:57:00 EST 1990

Below is the abstract of a forthcoming target article to appear in
Behavioral and Brain Sciences (BBS), an international,
interdisciplinary journal providing Open Peer Commentary on important
and controversial current research in the biobehavioral and cognitive
sciences. To be considered as a commentator or to suggest other appropriate
commentators, please send email to:
	 harnad at              or write to:
BBS, 20 Nassau Street, #240, Princeton NJ 08542  [tel: 609-921-7771]

Please specify the aspect of the article that you are qualified and
interested to comment upon. If you are not a current BBS Associate,
please send your CV and/or the name of a current Associate who would be
prepared to nominate you.

              The Neuropsychology of Schizophrenia
     J Gray,* J. Feldon,** JNP Rawlins,*** DR Helmsley* & AD Smith****

             *Institute of Psychiatary, London
             ** Psychology, Tel Aviv University
             *** Psychology, University of Oxford
             **** Pharmacology, University of Oxford

A model is proposed for integrating the neural and cognitive aspects
of the positive symptoms of acute schizophrenia using evidence from:
postmortem neuropathology and neurochemistry, clinical and preclinical
studies of dopaminergic neurotransmission, anatomical connections
between the limbic system and the basal ganglia, attentional and other
cognitive abnormalities underlying the positive symptoms of
schizophrenia, specific animal models of some of these abnormalities,
and previous attempts to model the cognitive functions of the
spetohippocampal system and the motor functions of the basal ganglia.
Anatomically, the model emphasises the projections from the
septohippocampal system, via the subiculum and the amygdala to nucleus
accumbens and their interaction with the ascending dopaminergic
projection to the accumbens. Psychologically, the model emphasizes a
failure in schizophrenia to integrate stored memories of past
regularieties of perceptual input with ongoing motor programs in the
control of current perception. A number of recent experiments that
offer support for the model are fully described, including anatomical
studies of limbic-striatal connections, studies in the rat of the
effects of damage to these connections and of the effects of
amphetamine and neuroleptics on the partial reinforcement extinction
effect, latent inhibition and the Kamin blocking effect, and studies
of the latter two phenomena in acuate and chronic schizophrenics.
Stevan Harnad  Department of Psychology  Princeton University
harnad at       srh at
harnad at    harnad at pucc.bitnet    (609)-921-7771

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