IgE/Transplantation

Milan JIRA ULIMJ%CSEARN at PUCC.PRINCETON.EDU
Sat Mar 9 14:49:05 EST 1991


> on March 4th 1991 at 10:36:52 GMT Michael Diffin said:
>   It has been put to me that IgE antibody has an important role
>   in transplant rejection. As yet I have not been able to find any evidence
  > of this - does anyone know of any, or perhaps a reference.
There are some informations about IgE in humans which might be helpful:
1. In 1987 we published a paper entitled Immunoglobulin E (IgE) in
   patients with severe burns (Burns 13, 1987, pp. 458-461). We found
   4 to 20 fold increase in total serum IgE one week after the burn
   injury. All patients are treated by skin allografts placed early
   after injury on all surfaces.
2. There we referenced Saryan J.A. at al.: J. Clin. Invest. 71,
1983, p.556. Theydecribed dramatic increase of IgE after bone marrow
   transplantation in patients with acute GVHD
3. I did not study IgE from 1987 any more but I feel that these data
   might be related to the subjcet and question you asked in this
   bulletin board.
There might be other scientists with more info on this IgE subject
Milan JIra, M.D., Ph.D.
3rd Medical School, Charles University
Srobarova 48, 100 42 Praha 10,
Czechoslovakia
E-mail: ULIMJ at CSEARN.BITNET



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