Biotechnology Lecture Series

FRANCES M. CARDILLO ARF6 at MANVAX.BITNET
Thu Oct 31 20:22:00 EST 1991


TO: Colleagues in the New York City Metropolitan Area

             Manhattan College Chapter of SIGMA XI,
                 THE SCIENTIFIC RESEARCH SOCIETY
                and THE BIOTECHNOLOGY PROGRAM of
         Manhattan College  / College of Mt. St. Vincent
                         Bronx, NY 10471

                            announce
         the First in a Series of Biotechnology Lectures

                      Dr. John J. Siekierka
       Merck, Sharp & Dohme Research Laboratories, Rahway, NJ

 FK-506 and Cyclosporin A: MOLECULAR PROBES FOR THE STUDY OF
                   T-CELL SIGNAL TRANSDUCTION
FK-506 and CsA are selective inhibitors of an early T-cell  acti-
vation  event which leads to the expression of a limited  set  of
lymphokine  genes.   They  are chemically distinct  and  bind  to
distinct cellular receptors, FKBP and cyclophilin.  However  both
drugs  appear to act at an identical site within the cell.   Both
drugs  are  members of a class of proteins  possessing  peptidyl-
prolyl cis-trans isomerase activity which catalyze the isomeriza-
tion  of Xaa-Pro peptide bonds and may play a role in  regulating
critical  transducing elements in T-cells.   Characterization  of
the  signaling  pathways affected by FK-506 and CsA  has  led  to
insights  concerning  the mechanism of these pathways  in  T-cell
activation.
               Wednesday, November 6, 1991  6 p.m.
                 Rodriques Room, Manhattan Hall
                     Manhattan College

                 THE PUBLIC IS CORDIALLY INVITED
         For additional information and
                transportation directions contact:
                     Dr. Frances M. Cardillo
                Director of Biotechnology Program
                          212-405-3279
                                 or

                        Dr. Abdijit Mitra
                   President, Sigma Xi Chapter
                          212-920-0350







More information about the Bioforum mailing list