EC: Enzyme comission

Amos Bairoch BAIROCH at CMU.UNIGE.CH
Wed Sep 11 14:06:00 EST 1991


<Does anyone out there know whether it is possible to inspect
<the current version of the EC (Enzyme Commision) numbers and names
<through electronic means? - or is it only available as a printed book?
<Is it possible to download EC-data from some source?
 
  The 'ENZYME'  data bank  contains the  following data  for each  type of
  characterized enzyme for which an EC number has been provided:
 
   -  EC number.
   -  Recommended name.
   -  Alternative names (if any).
   -  Catalytic activity.
   -  Cofactors (if any).
   -  Pointers to  the SWISS-PROT  entrie(s) that  correspond to the enzyme
      (if any).
   -  Pointers to disease(s) associated with a deficiency of the enzyme (if
      any).
 
 
   The main  source for  the data  in  the  ENZYME  data  bank  comes  from
   recommendations of the Nomenclature Committee of the International Union
   of Biochemistry  (NC-IUB) [1,2,3].  A minor  part of  the data  has been
   extracted from the literature.
 
   [1]  Enzyme Nomenclature, NC-IUB, Academic Press, New-York, (1984).
   [2]  Supplement 1: corrections and additions.
        Eur. J. Biochem. 157:1-26(1986).
   [3]  Supplement 2: corrections and additions.
        Eur. J. Biochem. 179:489-533(1989).
 
   Sample entry:
 
   ID   2.3.1.43
   DE   PHOSPHATIDYLCHOLINE--STEROL ACYLTRANSFERASE.
   AN   LECITHIN--CHOLESTEROL ACYLTRANSFERASE.
   AN   LCAT.
   AN   PHOSPHOLIPID--CHOLESTEROL ACYLTRANSFERASE.
   CA   PHOSPHATIDYLCHOLINE + STEROL = STEROL ESTER +
   CA   1-ACYLGLYCEROPHOSPHOCHOLINE.
   CC   -!- PALMITOYL, OLEOYL, AND LINOLEOYL CAN BE TRANSFERRED; A NUMBER OF
   CC       STEROLS, INCLUDING CHOLESTEROL, CAN ACT AS ACCEPTOR.
   DI   NORUM DISEASE; MIM:245900.
   DI   FISH-EYE DISEASE; MIM:136120.
   DR   P10480, GCAT$AERHY;  P04180, LCAT$HUMAN;  P16301, LCAT$MOUSE;
   DR   P18424, LCAT$RAT  ;
   //
 
   How to download a copy of ENZYME:
 
1) If you have access to a computer that is linked to Internet, you can
   obtain ENZYME from the following FTP servers:
 
   Name     : GenBank On-line Service
   Address  : genbank.bio.net (or 134.172.1.160)
   Login    : User=Anonymous  Password=Your name
   Directory: \pub\db\enzyme
 
   Name     : NCBI
   Address  : ncbi.nlm.nih.gov (or 130.14.20.1)
   Login    : User=Anonymous  Password=Your name
   Directory: \repository\ENZYME
 
 
2) If you have access to a computer which can send electronic mail to a
   BITNET address, you can get ENZYME by electronic mail from the EMBL
   file server.
 
   To do so, you must send a message to the following address:
 
               NETSERV at EMBL-HEIDELBERG.DE
 
   Your message should contain the following lines:
 
   get ENZYME:ENZYME.DAT
   get ENZYME:ENZUSER.TXT
   get ENZYME:ENZCLASS.TXT
 
3) ENZYME is also available on the SWISS-PROT tape or CD-ROM distributed
   by the EMBL Data library.
 
Best regards
Amos
 
*****************************************************************************
* Amos Bairoch                * Email: bairoch at cgecmu51.bitnet              *
* Dept. Medical Biochemistry  *    or  bairoch at cmu.unige.ch                 *
* C.M.U.                      * Tel  : +(41 22) 61 84 92                    *
* 1, rue Michel Servet        ***********************************************
* 1211 Geneva 4               * Ground rule for laboratory workers:         *
* Switzerland                 * When you don't know what you are doing,     *
*                             * do it neatly.                               *
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