Newly computed PAM250 matrix

[Mike Cherry]

Anyone doing protein sequence comparisons should check out the latest 
issue of Science and the article on the newly computed PAM250 matrix. They 
used Needleman and Wunsch to compared all protein sequences in the MIPS 
database. A new PAM250 matrix is one of the results. They also have some 
interested things to say about gap scores in protein sequence alignments. 

The reference for the paper is:

Gaston H. Gonnet, Mark A. Cohen and Steven A. Benner
Exhaustive Matching of the Entire Protein Sequence Database (1992)
Science 256:1443-1445.